摘要
目的探讨血清甲状旁腺激素(PTH)、骨型碱性磷酸酶(BLAP)、骨形态发生蛋白2(BMP-2)水平与老年骨质疏松性椎体压缩骨折(OVCF)患者经皮椎体成形术预后的关系。方法回顾性分析2022年1月至2023年9月在沧州市人民医院行经皮椎体成形术(PVP)治疗的82例老年OVCF患者的临床资料。出院6个月后采用Barthel指数(BI)分析患者预后,将患者分为预后良好组(BI评分>60分,n=60)和预后不良组(BI评分≤60分,n=22)。统计两组基础资料信息及血清PTH、BLAP、BMP-2水平;多因素Logistic分析影响OVCF患者预后不良的因素,并经受试者操作特征(ROC)曲线分析血清PTH、BLAP、BMP-2水平预测OVCF患者预后不良的效能。结果两组基础资料信息比较,差异均无统计学意义(P>0.05);预后不良组血清PTH水平为(78.56±11.54)pg/mL,显著高于预后良好组[(59.58±9.59)pg/mL],血清BLAP、BMP-2水平分别为(54.35±4.25)U/L、(120.97±17.57)pg/mL,显著低于预后良好组[(120.97±17.57)U/L、(147.62±20.46)pg/mL],差异均有统计学意义(P<0.05)。经多因素Logistic回归分析证实,血清PTH水平升高、BLAP、BMP-2水平降低均是影响OVCF患者预后不良的危险因素(P<0.05)。通过ROC曲线分析验证,血清PTH、BLAP和BMP-2水平均能作为评估OVCF患者预后不良的指标,曲线下面积分别为0.920、0.885、0.810,均有P<0.05。结论血清PTH水平升高,BLAP、BMP-2水平降低会影响老年OVCF患者经皮椎体成形术预后不良。
Objective To investigate the relationship between serum parathyroid hormone(PTH),bone alkaline phosphatase(BLAP)and bone morphogenetic protein 2(BMP-2)levels and the prognosis of percutaneous vertebroplasty(PVP)in elderly patients with osteoporotic vertebral compression fracture(OVCF).Methods The clinical data of 82 patients with OVCF who underwent PVP in Cangzhou People's Hospital from January 2022 to September 2023 were retrospectively analyzed.The prognosis of patients was analyzed by Barthel index(BI)6 months after discharge,and the patients were divided into the good prognosis group(BI score>60,n=60)and the poor prognosis group(BI score≤60,n=22).Basic data and serum levels of PTH,BLAP and BMP-2 were analyzed in the two groups.Multivariate Logistic analysis of the factors affecting the poor prognosis of OVCF patients,and the efficacy of serum PTH,BLAP and BMP-2 levels in predicting poor prognosis in patients with OVCF was analyze using the receiver operation characteristic(ROC)curve.Results There was no statistically significant difference in basic data between the two groups(P>0.05).The serum PTH level in the poor prognosis group was(78.56±11.54)pg/mL,which was significantly higher than that in the good prognosis group[(59.58±9.59)pg/mL],the serum BLAP and BMP-2 levels were(54.35±4.25)U/L and(120.97±17.57)pg/mL,respectively,which were significantly lower than those in the good prognosis group[(120.97±17.57)U/L,(147.62±20.46)pg/mL],and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis confirmed that the increase of serum PTH level and the decrease of BLAP and BMP-2 levels were the risk factors affecting the poor prognosis of OVCF patients(P<0.05).ROC curve analysis confirmed that serum PTH,BLAP and BMP-2 levels could be used as indicators to evaluate the poor prognosis of OVCF patients,and the areas under the curve were 0.920,0.885 and 0.810,respectively,with P<0.05.Conclusion The increase of serum PTH level and the decrease of BLAP and BMP-2 level will affect the poor prognosis of PVP in elderly patients with OVCF.
作者
冯红卫
李超
及宁
FENG Hong-wei;LI Chao;JI Ning(Department of Orthopedics,Cangzhou People's Hospital,Cangzhou Hebei 061000,China)
出处
《临床和实验医学杂志》
2025年第13期1418-1421,共4页
Journal of Clinical and Experimental Medicine
基金
河北省卫生健康委员会医学科学研究课题计划项目(编号:20251501)。
关键词
骨质疏松性椎体压缩骨折
甲状旁腺激素
骨型碱性磷酸酶
骨形态发生蛋白2
预后
Osteoporotic vertebral compression fracture
Parathyroid hormone
Bone alkaline phosphatase
Bone morphogenetic protein 2
Prognosis
