摘要
目的:探讨CT引导下经皮液氮冷冻消融治疗老年肺恶性肿瘤的临床价值。方法:回顾性分析2023年1—12月接受CT引导下经皮液氮冷冻消融治疗的56例老年肺恶性肿瘤患者(根治组49例,姑息组7例)的临床资料。采用改良实体瘤疗效评价标准(modified response evaluation criteria in solid tumors,mRECIST)评估术后疗效,记录并发症、视觉模拟评分(visual ana⁃logue scale,VAS)、C⁃反应蛋白(C⁃reactive protein,CRP)及美国东部肿瘤协作组(Eastern Cooperative Oncology Group Score,ECOG)评分变化。结果:56例均成功完成手术,气胸发生率28.57%(16/56),经治疗后恢复良好。根治组术后1、3、6个月完全缓解率分别为100.00%、91.83%、83.67%,姑息组部分缓解率分别为100.00%、85.71%、57.14%。ECOG评分从术前(3.2±0.6)分降至术后6个月(1.3±0.4)分(P<0.01)。结论:该技术安全有效,尤其适用于无法手术的老年患者,根治性消融短期疗效显著,姑息性治疗可改善生活质量。
Objective:To evaluate the clinical value of CT-guided percutaneous nitrogen cryoablation for elderly patients with pulmonary malignancies.Methods:Clinical data of 56 elderly patients(49 in the radical group,7 in the palliative group)who underwent CT-guided percutaneous cryoablation from January to December 2023 were retrospectively analyzed.Treatment efficacy was assessed by modified response evaluation criteria in solid tumors(mRECIST),with complications,visual analogue scale(VAS),C-reactive protein(CRP)and Eastern Cooperative Oncology Group Score(ECOG)scores recorded.Results:All 56 procedures were successfully completed,with a pneumothorax incidence of 28.57%(16/56),all recovering well after treatment.The complete response rates in the radical group at 1,3,and 6 months postoperatively were 100.00%,91.83%,and 83.67%,respectively,whereas the partial response rates in the palliative group were 100.00%,85.71%,and 57.14%.The ECOG score decreased from a preoperative value of 3.2±0.6 to 1.3±0.4 at 6 months postoperatively(P<0.01).Conclusion:This technique is safe and effective,particularly suitable for elderly patients ineligible for surgery.Radical ablation demonstrates significant short-term efficacy,while palliative treatment improves quality of life.
作者
黄义勤
周勇
刘艳虎
李亚东
甄福喜
李庆国
HUANG Yiqin;ZHOU Yong;LIU Yanhu;LI Yadong;ZHEN Fuxi;LI Qingguo(Department of Thoracic Surgery,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011;Cardiovascular Center,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011;Department of Thoracic Surgery,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《南京医科大学学报(自然科学版)》
北大核心
2025年第8期1170-1177,共8页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省重点研发计划(社会发展)(BE2021749)。
关键词
肺肿瘤
液氮冷冻消融
体层摄影术
CT引导
lung tumor
composite liquid nitrogen solid tumor ablation
tomography
CT guidance
