摘要
肿瘤骨转移作为晚期恶性肿瘤患者常见的终末期事件,严重影响患者的生活质量和生存预后,成为当前肿瘤治疗领域面临的重大临床挑战。随着肿瘤生物学研究的深入,骨转移治疗模式已从传统的姑息性治疗逐步向精准靶向干预转变。目前,临床治疗策略呈现多元化发展态势,包括放射治疗、免疫治疗、骨改良药物及小分子靶向药物等在内的多种治疗手段已取得显著进展。然而,现有治疗方案仍存在疗效个体差异显著、耐药性频发以及不良反应突出等问题。本文系统阐述肿瘤骨转移精准治疗的最新研究进展,深入分析不同治疗策略的优势与局限,并对未来研究方向和治疗前景进行展望,以期为优化临床实践和推动转化研究提供参考和借鉴。
Bone metastasis,as a common terminal event in patients with advanced malignant tumors,significantly impacts patientsquality of life and survival prognosis,posing a major clinical challenge in the field of oncology.With the deepening understanding of tumor biology,the treatment paradigm for bone metastasis has progressively shifted from traditional palliative care to precise targeted interventions.Currently,clinical treatment strategies have demonstrated diversified development,with various therapeutic approaches⁃including radiotherapy,immunotherapy,bone⁃modifying agents,and small⁃molecule targeted drugs—achieving notable clinical progress.However,existing treatment regimens still face challenges such as significant interindividual variability in efficacy,frequent drug resistance,and prominent adverse effects.This article systematically reviews the latest advances in precision therapy for bone metastasis,provides an in⁃depth analysis of the strengths and limitations of different treatment strategies,and offers perspectives on future research directions and therapeutic prospects,aiming to provide reference for optimizing clinical practice and promoting translational research.
作者
梁安南
樊浩
邢金毅
郑志发
赵丽娜
吴志宏
邱贵兴
LIANG Annan;FAN Hao;XING Jinyi;ZHENG Zhifa;ZHAO Lina;WU Zhihong;QIU Guixing(Department of Orthopedic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Stem Cell Facility,Institute of Clinical Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)
出处
《协和医学杂志》
北大核心
2025年第4期817-825,共9页
Medical Journal of Peking Union Medical College Hospital
基金
国家重点研发计划(2022YFC2703901)
中国工程院国家自然科学基金委联合战略研究与咨询项目(2024⁃ZCQ⁃18)
国家自然科学基金(82172525,82402760)
北京市自然科学基金(7244389)
中国医学科学院医学与健康科技创新工程(2021⁃I2M⁃1⁃052)
中央高水平医院临床科研专项(2022⁃PUMCH⁃D⁃002)。
关键词
肿瘤
骨转移
放疗
免疫治疗
骨改良药
靶向药物
tumor
bone metastasis
radiotherapy
immunotherapy
bone⁃modifying agents
targeted drugs
