摘要
糖疫苗及糖肽疫苗在肿瘤的预防与治疗领域展现出重要潜力,但其面临免疫原性较低等问题。佐剂被广泛用于增强对特定抗原的免疫响应,但外加佐剂仍存在诸多局限性,如免疫增强能力有限,分子扩散引发一定程度的安全性问题等。内嵌佐剂策略是将佐剂与疫苗抗原通过特定方式结合,使佐剂在疫苗体系中能更充分发挥效用的一种方法。本文归纳了不同激动剂分子(Toll样受体激动剂、iNKT细胞激动剂、干扰素基因刺激因子激动剂、核苷酸结合寡聚结构域样受体激动剂,以及C型凝集素受体激动剂等)作为内嵌佐剂在提升疫苗免疫原性方面的应用和研究进展,旨在为开发更高效、安全的糖疫苗提供参考。
Carbohydrate and glycopeptide vaccines have shown great promise in tumor prevention and treatment.However,their relatively low immunogenicity remains a significant challenge.To address this,adjuvants are commonly employed to enhance immune responses against specific antigens.Despite their widespread use,conventional adjuvants still face several limitations,including limited immune stimulation and potential safety concerns associated with molecular diffusion.A promising strategy to overcome these challenges is the incorporation of built-in adjuvants,which promotes adjuvants to augment their immunostimulatory effect.This review highlights the application of various immune agonists as built-in adjuvants to enhance vaccine immunogenicity,including Toll-like receptor(TLR)agonists,invariant natural killer T(iNKT)cell agonists,stimulator of interferon genes(STING)agonists,nucleotide-binding oligomerization domain-like receptors(NLR)agonists,and C-type lectin receptor(CLR)agonists.By summarizing recent advancements in this field,we provide valuable insights into the development of more effective and safer carbohydrate vaccines.
作者
张如岩
文雨
赵文翔
苏振宏
杜晶晶
郭军
ZHANG Ru-yan;WEN Yu;ZHAO Wen-xiang;SU Zhen-hong;DU Jing-jing;GUO Jun(Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention,College of Medicine,Hubei Polytechnic University,Huangshi 435003,China;International Joint Research Center for Intelligent Biosensing Technology and Health,National Key Laboratory of Green Pesticide,College of Chemistry,Central China Normal University,Wuhan 430079,China)
出处
《药学学报》
北大核心
2025年第7期2002-2015,共14页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(22477039,22177035,22207033)
中央高校基本科研业务费专项资金(CCNU25JC034)
中国高校引进学科人才计划(111 program B17019)
湖北省高校优秀中青年科技创新团队项目(T2023033)
湖北省自然科学基金(2025AFB448)
肾脏疾病发生与干预湖北省重点实验室开放基金项目(2023SB105,2024SJ103)
湖北理工学院人才引进项目(24xjz30R)
关键词
抗肿瘤疫苗
佐剂-抗原偶联物
糖抗原
糖肽抗原
免疫治疗
anti-tumor vaccine
adjuvant-antigen conjugate
carbohydrate antigen
glycopeptide antigen
immunotherapy
