摘要
目的本研究旨在探讨异甘草酸镁(magnesium isoglycyrrhizinate,MgIG)联合奥曲肽(octreotide,OCT)治疗对乙肝肝硬化上消化道出血(UGB)患者的影响。方法方法研究时间为2023年1月-2024年10月,选取我院收治的80例乙肝肝硬化UGB患者,按照随机数表法分为MgIG+OCT组(采用MgIG联合OCT治疗)和OCT组(采用OCT治疗),每组各40例。比较两组患者治疗1周后的临床疗效,以及治疗前后血流动力学指标和肝功能指标的变化。结果结果MgIG+OCT组患者治疗总有效率为97.50%,高于OCT组的82.50%(P<0.05)。治疗后MgIG+OCT组患者止血时间、住院时间、输血量、48h内再出血率明显低于OCT组(P<0.05)。OCT组与MgIG+OCT组患者治疗后血清ALT、AST、TBIL水平,门静脉血流量、脾静脉血流量水平明显低于治疗前,且MgIG+OCT组明显低于OCT组(P<0.05)。结论结论MgIG与OCT联合干预,可有效改善乙肝肝硬化UGB患者的肝功能及血流动力学相关指标,且临床疗效较好。
Objective The aim of this study was to investigate the effect of treatment with magnesium isoglycyrrhizinate(MgIG)combined with octreotide(OCT)on patients with hepatitis B cirrhotic upper gastrointestinal bleeding(UGB).Methods Eighty patients with hepatitis B cirrhosis UGB admitted to our hospital were selected,and the study period was from January 2023 to October 2024,and they were divided into the MgIG+OCT group(treated with MgIG combined with OCT)and the OCT group(treated with OCT)according to the method of randomized numerical table,each with 40 cases.Compare the clinical efficacy of two groups of patients after one week of treatment,as well as changes in hemodynamic and liver function indicators before and after treatment.Results The total effective rate of treatment of patients in MgIG+OCT group was 97.50%,which was higher than that of 82.50%in OCT group(P<0.05).The hemostasis time,hospitalization time,blood transfusion volume,and rebleeding rate within 48h were significantly lower in the MgIG+OCT group than in the OCT group after treatment(P<0.05).The levels of serum ALT,AST,and TBIL,portal venous blood flow,and splenic venous blood flow were significantly lower in the patients of the OCT group and the MgIG+OCT group after treatment,and the MgIG+OCT group was lower than the OCT group(P<0.05).Conclusion The combined intervention of MgIG and OCT can effectively improve the liver function and hemodynamic related indexes in patients with hepatitis B cirrhosis UGB,and the clinical efficacy is better.
作者
周朝平
Zhou Chaoping(Guangfeng District People’s Hospital,Shangrao,Jiangxi 334600,China)
出处
《首都食品与医药》
2025年第16期75-77,共3页
Capital Food Medicine
关键词
奥曲肽
异甘草酸镁
乙肝肝硬化
上消化道出血
血流动力学
Octreotide
Magnesium isoglycyrrhizate
Hepatitis B cirrhosis
Upper gastrointestinal hemorrhage
Hemodynamics
