摘要
目的:分析肝硬化患者发生上消化道出血(UGB)的影响因素。方法:选取2021年11月至2023年10月该院收治的98例肝硬化患者进行横断面研究,统计肝硬化患者UGB发生情况,并根据是否发生UGB将其分为发生组与未发生组,采用Logistic回归分析肝硬化患者发生UGB的影响因素。结果:98例肝硬化患者中,发生UGB 46例,发生率为46.94%(46/98);两组性别、年龄、肝硬化类型、腹水情况、消化道出血史、消化性溃疡、门静脉高压性胃病、不良饮食习惯、饮酒史、使用质子泵抑制剂、使用抗血小板药物、使用非甾体药物、凝血酶原时间比较,差异均无统计学意义(P>0.05);发生组肝硬化病程≥5年、肝功能Child-Pugh分级为C级、食管静脉曲张程度为重度、前白蛋白(PA)<100 mg/L、血小板体积分布宽度(PDW)<16.5%、血小板压积(PCT)<0.30%、平均血小板体积(MPV)<7 fL、血小板计数(PLT)<300×10^(9)/L占比均高于未发生组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,肝功能Child-Pugh分级为C级、食管静脉曲张程度为重度、PA<100 mg/L、PCT<0.30%均为肝硬化患者发生UGB的危险因素(OR>1,P<0.05)。结论:肝功能Child-Pugh分级为C级、食管静脉曲张程度为重度、PA<100 mg/L、PCT<0.30%均为肝硬化患者发生UGB的危险因素。
Objective:To analyze influencing factors of upper gastrointestinal bleeding(UGB)in patients with liver cirrhosis.Methods:A cross-sectional study was conducted on 98 patients with liver cirrhosis admitted to the hospital from November 2021 to October 2023.The occurrence of UGB in these patients with cirrhosis was statistically analyzed.According to whether UGB occurs,these patients were divided into occurrence group and non-occurrence group.Logistic regression was used to analyze the influencing factors of UGB in the patients with liver cirrhosis.Results:Of the 98 patients with liver cirrhosis,46 had UGB,with an incidence of 46.94%(46/98).There were no significant differences in gender,age,type of cirrhosis,ascites,history of gastrointestinal bleeding,peptic ulcer,portal hypertensive gastropathy,bad eating habits,drinking history,use of proton pump inhibitors,use of antiplatelet drugs,use of non-steroidal drugs,and prothrombin time between the two groups(P>0.05).The proportions of the patients with cirrhosis course≥5 years,liver function Child-Pugh grade C,severe esophageal varices,prealbumin(PA)<100 mg/L,platelet distribution width(PDW)<16.5%,platelet hematocrit(PCT)<0.30%,mean platelet volume(MPV)<7 fL,platelet count(PLT)<300×10^(9)/L in the occurrence group were higher than those in the non-occurrence group,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that Child-Pugh grade C,severe esophageal varices,PA<100 mg/L and PCT<0.30%were risk factors for UGB in the patients with liver cirrhosis(OR>1,P<0.05).Conclusions:Liver function Child-Pugh grade C,severe esophageal varices,PA<100 mg/L,and PCT<0.30%are the risk factors for UGB in the patients with cirrhosis.
作者
王娟
王秀敏
孟敏
WANG Juan;WANG Xiumin;MENG Min(Department of Gastroenterology of the People’s Hospital of Anyang City,Anyang 455000 Henan,China)
出处
《中国民康医学》
2025年第11期15-18,共4页
Medical Journal of Chinese People’s Health
关键词
肝硬化
上消化道出血
食管静脉曲张
影响因素
Liver cirrhosis
Upper gastrointestinal bleeding
Esophageal varices
Influencing factor
