摘要
舍曲林作为临床广泛应用的强效选择性5-羟色胺再摄取抑制剂(SSRI),其稳态血药浓度在常规给药剂量下存在显著的个体差异。这种差异源于多因素,包括剂量、年龄、肝功能状态、合并用药情况以及遗传多态性等影响。本综述系统分析影响舍曲林血药浓度的关键因素(涵盖剂量、人口学特征、生理病理状态及药物相互作用等方面),旨在为临床制定个体化给药方案提供循证依据,以优化治疗效果并确保用药安全。
As a potent and selective serotonin reuptake inhibitor(SSRI)widely used in clinical practice,sertraline has significant inter-individual differences in its steady-state plasma concentration under conventional doses.This difference stems from multifactorial effects,including dose,age,liver function status,concomitant medication status,and drug metabolism-related factors such as genetic polymorphisms.This review systematically analyzed the key factors affecting sertraline blood concentration(including dose,demographic characteristics,physiopathological status,and drug interactions),aiming to provide evidence-based basis for the clinical formulation of individualized dosing regimens,so as to optimizethe treatment effect and ensure drug safety.
作者
自雪梅
王晶晶
ZI Xuemei;WANG Jingjing(Clinical Research Center of The People's Hospital of Chuxiong Yi Autonomous Prefecture,Chuxiong 675000,China;Clinical Research Center of The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)
出处
《中国临床药学杂志》
2025年第6期476-480,共5页
Chinese Journal of Clinical Pharmacy
基金
国家自然科学基金(编号82460737)
云南省应用基础研究-昆明医科大学联合专项(编号202401AY070001-034)。
关键词
舍曲林
血药浓度
影响因素
sertraline
blood drug concentration
influencing factor
