摘要
目的:研究老年糖尿病肾病患者血清及尿液视黄醇结合蛋白(RBP)、α1-微球蛋白(α1-MG)、转铁蛋白(TRF)水平的变化及意义。方法:选取2021年7月—2022年12月黔西南州中医院收治的81例老年糖尿病肾病患者作为试验组,另选取65例老年单纯糖尿病患者作为对照组,两组均于就诊当日检测血清与尿液RBP、α1-MG、转铁蛋白水平。比较两组血清与尿液RBP、α1-MG、转铁蛋白水平,随后比较试验组不同肾损伤分期患者上述指标的差异,分析研究指标与肾功能的相关性。结果:试验组血清RBP、α1-MG水平以及尿液RBP、α1-MG、TRF水平均高于对照组,血清TRF水平低于对照组,差异有统计学意义(P<0.05)。Ⅲ期和Ⅳ期肾损伤患者血清RBP、α1-MG以及尿液RBP、α1-MG、TRF水平均高于Ⅱ期患者,血清TRF水平低于Ⅱ期患者,差异有统计学意义(P<0.05)。血清RBP、α1-MG水平以及尿液RBP、α1-MG、TRF水平均与糖尿病肾病严重程度呈正相关关系,血清TRF水平与糖尿病肾病严重程度呈负相关关系,差异有统计学意义(P<0.05)。结论:糖尿病肾病患者血清RBP、α1-MG与尿液RBP、α1-MG、TRF水平呈现异常升高,血清TRF水平异常降低,且以上变化均与糖尿病肾病严重程度密切相关,监测血清及尿液RBP、α1-MG、TRF水平有助于临床及早诊断糖尿病肾病及监测病情进展。
Objective:To study the changes and significance of retinol-binding protein(RBP),α1-microglobulin(α1-MG),and transferrin(TRF)levels in the serum and urine of elderly patients with diabetic nephropathy.Method:81 elderly patients with diabetic nephropathy admitted to Qianxinan Prefecture Hospital of Traditional Chinese Medicine from July 2021 to December 2022 were selected as the experimental group,and another 65 elderly patients with simple diabetes were selected as the control group.The levels of serum and urine RBP,α1-MG,and transferrin in both groups were detected on the day of visit.The levels of RBP,α1-MG and transferrin in serum and urine of the two groups of patients were compared.Then,the differences of the above indicators among patients with different stages of renal injury in the experimental group were compared,and the correlation between the research indicators and renal function was analyzed.Result:The levels of serum RBP andα1-MG,as well as the levels of urine RBP,α1-MG and TRF in the experimental group were all higher than those in the control group,while the level of serum TRF was lower than that in the control group.The differences were statistically significant(P<0.05).The levels of serum RBP andα1-MG,as well as the levels of urine RBP,α1-MG and TRF in patients with stageⅢand stageⅣrenal injury were all higher than those in patients with stageⅡ,while the level of serum TRF was lower than that in patients with stageⅡ,and the differences were statistically significant(P<0.05).The levels of serum RBP andα1-MG,as well as the levels of urine RBP,α1-MG and TRF,were all positively correlated with the severity of diabetic nephropathy.The level of serum TRF was negatively correlated with the severity of diabetic nephropathy,and the differences were statistically significant(P<0.05).Conclusion:The levels of serum RBP andα1-MG in patients with diabetic nephropathy abnormally increase compared with the levels of urine RBP,α1-MG and TRF,and the level of serum TRF abnormally decreases.Moreover,all the above changes are closely related to the severity of diabetic nephropathy.Monitoring the levels of RBP,α1-MG and TRF in serum and urine is helpful for the early clinical diagnosis of diabetic nephropathy and the monitoring of disease progression.
作者
覃金燕
QIN Jinyan(Qianxinan Traditional Chinese Medicine Hospital,Qianxinan Prefecture 562400,China)
出处
《中外医学研究》
2025年第20期19-22,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
