摘要
目的观察国产比索洛尔对高血压合并2型糖尿病患者糖代谢及血压的影响情况。方法将符合纳入标准的高血压合并2型糖尿病患者随机分组。观察治疗前后患者糖化血红蛋白(HbA1c)、空腹血糖、糖耐量和血压等的变化。结果共有92例患者完成研究,其中比索洛尔组47例,卡托普利组45例。治疗前和经12周治疗后两组HbA1c、空腹血糖、餐后2h血糖、收缩压和舒张压差异均无统计学意义(P=0.05)。结论本研究表明比索洛尔作为高选择性β1受体阻滞剂,对于原发性高血压合并2型糖尿病患者糖代谢无明显不良影响,同时具有良好的降压效果。
Objective To investigate the effects of bisoprolol on glucose metabolism and blood pressure in essential hypertensive patients with type 2 diabetes mellitus. Methods A total of 92 hypertensive patients with type 2 diabetes on stable antidiabetic therapy with HbAlc less than 7% were recruited. In a randomized, open trial the patients were treated for 12 weeks with bisoprolol or captopril following a 1-week placebo run-in period, the main parameters measured were HbA1c, fasting blood glucose and 2-hour postprandial glucose following a standard dinner as well as systolic and diastolic blood pressure. Results There were no differences in HbA1[(6.0±0.8 )% vs (6.2±0.8 )%,P>0.05], fasting glucose[(7.0±1.8)mmol/L vs( 7.0±1.9)mmol/L, P>0.05 ], 2-hour postprandial blood glucose [(10.7±2.5)mmol/L vs (11.2±3.4)mmol/L, P>0.05], systolic blood pressure [(147.3±9.7)(mm Hg)(1 mm Hg=0.133 kPa) vs( 146.2±8.3)mm Hg, P>0.05]and diastolic blood pressure (88.3±8.9 mm Hg vs 87.8±7.9 mm Hg, P>0.05) between the bisoprolol and captopril group before treatment. After administration of bisoprolol or captopril, there were still no differences between these two groups in HbA1c[ (5.7±0.9)% vs (5.7±1.1)%, P>0.05], fasting blood glucose [(6.8±1.6)mmol/L vs (6.4±2.1)mmol/L, P>0.05], 2-hour postprandial glucose [(10.0±2.9)mmol/L vs (10.2±±2.9)mmol/L, P>0.05], systolic blood pressure[ (124.8±10.6)mm Hg vs(126.6±7.8)mm Hg,P>0.05]and diastolic blood pressure[ (74.5±7.7)mm Hg vs (77.6±7.6)mm Hg, P=0.05]. Conclusions(Based) on these results, bisoprolol appears to be a β1-slective blocker possessing a satisfactory antihypertensive effect without any adverse effects on glucose metabolism and is therefore a choice for treatmenting hypertensive patients with type 2 diabetes mellitus.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2005年第7期503-505,共3页
Chinese Journal of Internal Medicine
