摘要
目的:探讨复方甘露醇联合甘油果糖对急性脑出血(AICH)患者神经功能及血清炎症因子的影响。方法:选取2022年1月至2022年6月于通许第一医院就诊的80例AICH患者为研究对象,采用随机数字表法分为对照组和观察组,各40例。对照组患者接受复方甘露醇治疗,观察组患者接受复方甘露醇联合甘油果糖治疗。比较两组患者临床疗效,治疗前、治疗14 d后神经功能评分及计算机断层扫描(CT)结果(水肿、血肿),脑血流动力学指标[脑血流量(CBF)、平均血流速度(Vm)、收缩期峰值血流速度(PSV)],血清炎症因子[白细胞介素-1β(IL-1β)、超敏C反应蛋白(hs-CRP)、中枢神经特异性蛋白(S100β)]水平及预后情况。结果:观察组患者临床总有效率高于对照组,差异具有统计学意义(P<0.05);治疗14 d后,两组患者神经功能评分、水肿、血肿水平均低于治疗前,且观察组均低于对照组,差异均具有统计学意义(P<0.05);治疗14 d后,两组患者CBF、Vm、PSV水平均高于治疗前,且观察组均高于对照组,差异均具有统计学意义(P<0.05);治疗14 d后,两组患者血清IL-1β、hs-CRP、S100β水平低于治疗前,且观察组均低于对照组,差异均具有统计学意义(P<0.05);两组患者再出血率、病死率比较,差异无统计学意义(P>0.05)。结论:复方甘露醇联合甘油果糖治疗AICH疗效显著,不仅能改善神经功能,缩小水肿、血肿,还能调节脑血流动力学,降低体内炎症反应,并具有一定的安全性。
Objective To explore the effects of compound mannitol combined with glycerol fructose on neurological function and serum inflammatory factors in patients with acute intracerebral hemorrhage(AICH).Methods A total of 80 patients with AICH who were treated at Tongxu First Hospital from January 2022 to June 2022 were selected as the research subjects and randomly divided into a control group and an observation group using a random number table,with 40 cases in each group.The control group was treated with compound mannitol,while the observation group was treated with compound mannitol combined with glycerol fructose.The clinical efficacy,neurological function scores,computed tomography(CT)results(edema and hematoma levels),cerebral hemodynamic parameters[cerebral blood flow(CBF),mean blood flow velocity(Vm),peak systolic velocity(PSV)],the levels of serum inflammatory factors[interleukin-1β(IL-1β),high-sensitivity C-reactive protein(hs-CRP),S100β],and prognosis of the two groups were compared before treatment and 14 days after treatment.Results The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After 14 days of treatment,the neurological function scores,edema and hematoma levels of both groups were lower than those before treatment,and those of the observation group were lower than those of the control group,with statistically significant differences(P<0.05).After 14 days of treatment,the levels of CBF,Vm and PSV of both groups were higher than those before treatment,and those of the observation group were higher than those of the control group,with statistically significant differences(P<0.05).After 14 days of treatment,the levels of serum IL-1β,hs-CRP and S100βof both groups were lower than those before treatment,and those of the observation group were lower than those of the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the rebleeding rate and mortality rate between the two groups(P>0.05).Conclusion The combination of compound mannitol and glycerol fructose in the treatment of AICH is effective,can improve neurological function,reduce edema and hematoma,regulate cerebral hemodynamics,and reduce the inflammatory response in the body,and has certain safety.
作者
张利娜
施迎兵
ZHANG Lina;SHI Yingbing(The Second Department of Neurology,Tongxu First Hospital,Henan Tongxu 475476)
出处
《深圳中西医结合杂志》
2025年第6期5-9,共5页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
急性脑出血
复方甘露醇
甘油果糖
神经功能
血清炎症因子
Acute intracerebral hemorrhage
Compound mannitol
Glycerol fructose
Neurological function
Serum inflammatory factors
