摘要
目的 分析七叶皂苷钠对下肢骨折术后患者患肢肿胀及疼痛程度的影响。方法 68例下肢骨折手术患者,以信封法分为比照组、实践组,各34例。比照组行甘露醇治疗,实践组行七叶皂苷钠治疗。比较两组临床疗效、肿胀和疼痛评分、骨代谢指标[骨钙素(BGP)、骨碱性磷酸酶(BALP)]、炎症指标[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]及术后恢复时间。结果 实践组总有效率为97.06%,高于比照组的76.47%(P<0.05)。治疗前,两组肿胀、疼痛评分比较差异性不明显(P>0.05);治疗后,两组肿胀、疼痛评分均有较大降幅,且实践组肿胀评分(0.76±0.12)分、疼痛评分评分(1.01±0.36)分均低于比照组的(1.03±0.25)、(1.62±0.40)分(P<0.05)。治疗前,两组BGP、BALP水平比较差异性不明显(P>0.05);治疗后,两组BGP、BALP水平均有较大增幅,且实践组均BGP(7.71±0.42)μg/L、BALP(86.12±3.04)U/L高于比照组的(6.69±0.73)μg/L、(79.84±4.61)U/L(P<0.05)。治疗前,两组TNF-α、CRP水平比较差异性不明显(P>0.05);治疗后,两组TNF-α、CRP水平均有较大降幅,且实践组TNF-α(403.92±37.54)ng/L、CRP(63.09±4.52)mg/L均低于比照组的(461.77±40.75)ng/L、(70.17±4.43)mg/L(P<0.05)。实践组皮纹出现时间(5.64±1.09)d、肿胀消退时间(4.43±1.31)d、卧床时间(6.18±1.72)d、出院时间(12.81±1.95)d均短于比照组的(6.98±1.22)、(6.09±1.75)、(8.94±1.54)、(17.66±2.04)d(P<0.05)。结论 七叶皂苷钠联合甘露醇能更快速消除患肢肿胀并缓解患肢痛感,可缩短下肢骨折术后恢复时间,改善骨代谢指标并抑制炎症,提升骨折术后转归。
Objective To analyze the effect of sodium aescinate on the swelling and pain level of the affected limbs of postoperative patients with lower limb fracture.Methods 68 patients undergoing lower limb fracture surgery were divided into a control group and a practice group by the envelope method,with 34 cases in each group.The control group was treated with mannitol,while the practice group was treated with sodium aescinate.Both groups were compared in terms of clinical efficacy,swelling and pain scores,bone metabolism indicators[bone glaprotein(BGP),bone alkaline phosphatase(BALP)],inflammatory indicators[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]and postoperative recovery time.Results The total effective rate of the practice group was 97.06%,which was higher than 76.47%of the control group(P<0.05).Before treatment,there was no significant difference in swelling and pain scores between the two groups(P>0.05).After treatment,the swelling and pain scores in both groups decreased significantly;the swelling score in the practice group was(0.76±0.12)points and the pain score was(1.01±0.36)points,both of which were lower than(1.03±0.25)and(1.62±0.40)points in the control group(P<0.05).Before treatment,there was no significant difference in the levels of BGP and BALP between the two groups(P>0.05).After treatment,the levels of BGP and BALP in both groups increased significantly;the practice group had BGP of(7.71±0.42)μg/L and BALP of(86.12±3.04)U/L,which were higher than(6.69±0.73)μg/L and(79.84±4.61)U/L in the control group(P<0.05).Before treatment,there was no significant difference in the levels of TNF-αand CRP between the two groups(P>0.05).After treatment,the levels of TNF-αand CRP in both groups decreased significantly;the practice group had TNF-αof(403.92±37.54)ng/L and CRP of(63.09±4.52)mg/L,which were lower than(461.77±40.75)ng/L and(70.17±4.43)mg/L in the control group(P<0.05).In the practice group,the appearance time of skin wrinkles was(5.64±1.09)d,the time of swelling subsidence was(4.43±1.31)d,the time of bed rest was(6.18±1.72)d,and the discharge time was(12.81±1.95)d,which were all shorter than(6.98±1.22),(6.09±1.75),(8.94±1.54),and(17.66±2.04)d in the control group(P<0.05).Conclusion Sodium aescinate combined with mannitol can eliminate swelling of the affected limb more quickly and relieve pain in the affected limb.It can shorten the recovery time after lower limb fracture surgery,improve bone metabolism indicators and inhibit inflammation,enhance postoperative outcomes.
作者
王海峰
石念龙
WANG Hai-feng;SHI Nian-long(Department of Surgery,Zhuge Town Central Health Center,Yishui County,Linyi 276422,China)
出处
《中国实用医药》
2025年第13期118-121,共4页
China Practical Medicine
关键词
下肢骨折
七叶皂苷钠
肿胀
疼痛
炎症指标
Lower limb fracture
Sodium aescinate
Swelling
Pain
Inflammatory indicators
