摘要
目的:探讨益生菌辅助米诺环素治疗老年慢性牙周炎(CP)患者的临床效果。方法:纳入2021年1月~2023年3月本院95例老年CP患者,随机数字表法分为观察组(49例)与对照组(46例)。2组均进行口腔卫生宣教,对照组接受牙周规范治疗,观察组在牙周规范治疗基础上予以益生菌含片治疗,2组均治疗4周。统计2组疗效、不良反应发生情况,比较治疗前后牙周指数[附着丧失(AL)、探诊深度(PD)、出血指数(BI)]、口腔菌群(唾液乳酸杆菌、牙龈卟啉单胞菌浓度)、口腔健康状态[口腔健康评估量表(OHAT)评分]。结果:2组无剔除病例。治疗后观察组总有效率95.92%高于对照组80.43%(P<0.05)。治疗后2组AL、PD、BI值低于治疗前(P<0.05),且观察组AL、PD、BI值低于对照组(P<0.05)。治疗后2组唾液牙龈卟啉单胞菌浓度低于治疗前,唾液乳酸杆菌浓度高于治疗前(P<0.05);且观察组唾液牙龈卟啉单胞菌浓度低于对照组,唾液乳酸杆菌浓度高于对照组(P<0.05)。治疗后2组OHAT评分低于治疗前(P<0.05),且观察组OHAT评分低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:益生菌辅助米诺环素治疗老年CP患者,可降低牙周指数,调节口腔菌群,改善口腔健康状态,且未增加不良反应。
Objective:To investigate the clinical effect of probiotic-assisted minocycline in the treatment of elderly patients with chronic periodontitis(CP).Methods:95 elderly patients with CP in our hospital from January 2021 to March 2023 were selected and divided into observation group(49 cases)and control group(46 cases)by random number table method.Both groups received oral health education,the control group received standard periodontal treatment,the observation group was given probiotic lozenges,and both groups were treated for 4 weeks.The therapeutic effect and occurrence of adverse reactions in the 2 groups were analyzed,and the periodontal index[loss of attachment(AL),probing depth(PD),bleeding index(BI)],oral flora(concentrations of Lactobacillus salivary and porphyromonas gingivalis)and oral health status[oral health assessment tool(OHAT)score]before and after treatment were compared.Results:No cases were excluded in 2 groups.After treatment,the total effective rate of observation group was 95.92%higher than that of control group 80.43%(P<0.05).After treatment,the values of AL,PD and BI in the 2 groups were lower than before treatment(P<0.05),and the values of AL,PD and BI in the observation group were lower than those in the control group(P<0.05).After treatment,the concentration of porphyromonas gingivalis in saliva in 2 groups was lower than that before treatment,and the concentration of lactobacillus in saliva was higher than that before treatment(P<0.05).The concentration of porphyromonas gingivalis in saliva in observation group was lower than that in control group,and the concentration of lactobacillus in saliva was higher than that in control group(P<0.05).After treatment,the OHAT score of the 2 groups was lower than that before treatment(P<0.05),and the OHAT score of the observation group was lower than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Probiotics assisted minocycline in the treatment of elderly patients with CP can reduce periodontal index,regulate oral flora and improve oral health without increasing adverse reactions.
作者
马艳茹
宋恒国
宋双
杨杰
李世英
MA Yanru;SONG Hengguo;SONG Shuang;YANG Jie;LI Shiying(Department of Stomatology,Affiliated Hospital of Heze Medical College,Shandong Province,274000,China)
出处
《实用口腔医学杂志》
北大核心
2025年第4期490-494,共5页
Journal of Practical Stomatology
关键词
慢性牙周炎
老年
益生菌
米诺环素
口腔菌群
牙周指数
Chronic periodontitis
Elderly
Probiotics
Minocycline
Oral flora
Periodontal index
