摘要
目的:评估定量CT在结缔组织病相关间质性肺异常(CTD-ILA)和结缔组织病相关间质性肺疾病(CTD-ILD)中的诊断效能,建立基于定量CT的结缔组织病(CTD)患者筛查方法。方法:纳入CTD-ILD患者140例、CTD-ILA患者33例、对照组109例,使用3D-Slicer获得定量指标。结果:各组间定量CT指标均存在差异;ROC分析显示,F%、GGO%、SD及Kurtosis是鉴别对照组与CTD-ILA/ILD的敏感指标,其中SD在早期诊断CTD-ILA(AUC=0.862)、CTD-ILD(AUC=0.923)时表现最佳,进一步区分CTD-ILA与CTD-ILD时,SD(AUC=0.649)和F%(AUC=0.617)展现出较强区分能力。多元逐步Logistic回归分析显示,F%、GGO%、SD和Kurtosis在区分对照组与CTD-ILA/ILD时具有统计学意义。结论:定量CT对于CTD-ILA/ILD早期诊断具有重要意义,基于定量CT构建CTD筛查流程有助实现患者精准管理。
Objective:The aim of this study is to evaluate the diagnostic efficacy of quantitative computed tomography(CT)in differentiating between connective tissue disease-associated interstitial lung abnormalities(CTD-ILA)and connective tissue disease-associated interstitial lung disease(CTD-ILD),as well as to establish a screening protocol for connective tissue disease(CTD)patients based on quantitative CT.Methods:A total of 140 patients with CTD-ILD,33 patients with CTD-ILA,and 109 healthy controls were enrolled.Quantitative indices were obtained using the 3D-Slicer software.Results:Significant differences in quantitative CT indices are observed among the groups.ROC analysis shows that the F%,GGO%,SD,and kurtosis are sensitive indicators for differentiating the control group from those with CTD-ILA/ILD.Notably,the best SD is demonstrated in the early diagnosis of both the CTD-ILA(AUC=0.862)and CTD-ILD(AUC=0.923)groups.Further distinguishing between CTD-ILA and CTD-ILD shows the strong discriminatory ability of the SD(AUC=0.649)and F%(AUC=0.617).Multivariable stepwise logistic regression analysis shows that F%,GGO%,SD,and kurtosis are statistically significant in differentiating the control group from the CTD-ILA/ILD groups.Conclusion:Quantitative CT is promising for the early diagnosis of CTD-ILA/ILD.Establishing a CTD screening protocol based on quantitative CT can facilitate precise patient management.
作者
王珂
冀韩英
黄晓旗
潘娟
WANG Ke;JI Hanying;HUANG Xiaoqi;PAN Juan(Department of Radiology,Yan’an University Affiliated Hospital,Yan’an 716000,China;General Practice Department,Yan’an People’s Hospital,Yan’an 716000,China)
出处
《CT理论与应用研究(中英文)》
2025年第4期611-620,共10页
Computerized Tomography Theory and Applications
基金
陕西省科技厅重点研发计划(基于体素对吸烟者肺结构损伤的定量研究(2021SF-254))
延安大学教育创新项目(基于定量CT评估类风湿关节炎相关间质性肺疾病(YCX2024116))。
关键词
定量CT
结缔组织病
间质性肺疾病
间质性肺异常
quantitative CT
connective tissue disease
interstitial lung disease
interstitial lung abnormalities
