摘要
目的使用DTI技术中基于纤维束的空间统计分析方法探讨非神经精神性系统性红斑狼疮患者脑白质微结构的变化及其与神经精神量表、临床指标的相关性。方法前瞻性对42例女性non-NPSLE患者和45例女性健康对照者进行DTI检查。使用各项异性分数(FA)来评估non-NPSLE和健康对照组在结构水平上的差异。在non-NPSLE患者中,采用spearman相关性分析来探讨差异脑区FA值与神经精神量表、临床指标之间的关系。结果与健康对照组相比,non-NPSLE患者在左侧内囊前支、左侧上额枕束、左侧前、上放射冠、胼胝体体部FA值降低。在non-NPSLE组中,左侧上额枕束FA值与抗dsDNA抗体、IgM抗体呈正相关,与发病时间呈负相关;左侧上放射冠FA值与IgM抗体呈正相关;胼胝体体部FA值与IgM抗体、MMSE呈正相关。结论non-NPSLE患者多个白质区的FA值存在异常,且部分白质区的FA值与MMSE量表评分、临床指标之间存在一定的相关性,这可能揭示了non-NPSLE患者的潜在发病机制,白质区的FA值改变可能是non-NPSLE患者脑白质微结构异常的潜在影像学标志物。
Objective To investigate the changes in the microstructure of leukoplasm in patients with nonneuropsychiatric systemic lupus erythematosus and its correlation with neuropsychiatric scales and clinical indicators using spatial statistical analysis methods based on fiber bundles in DTI technology.Methods DTI examination was prospectively performed on 42 female non-NPSLE patients and 45 female healthy controls.Individual heterosexual scores(FA)were used to assess differences at the structural level between non-NPSLE and healthy controls.In patients with non-NPSLE,the relationship between differential brain area FA values and neuropsychiatric scales and clinical indicators was explored by speedman correlation analysis.Results Compared with the healthy control group,patients with non-NPSLE had lower FA values in the left medial anterior branch of the posterior capsule,the left superior forehead occipital bundle,the left anterior,the upper radiating crown,and the callosum body.In the non-NPSLE group,the LEFT upper occipital bundle FA value was positively correlated with anti-dsDNA antibody and IgM antibody,and negatively correlated with the time of onset.Left upper radiant crown FA value is positively correlated with IgM antibody;The FA value of the callosum body is positively correlated with IgM antibody and MMSE.Conclusion There are abnormalities in the FA values of multiple white matter areas in non-NPSLE patients,and there is a certain correlation between the FA values of some white matter areas and MMSE scale scores and clinical indicators,which may reveal the potential pathogenesis of non-NPSLE patients,and FA values in white matter areas may be potential imaging markers of white matter microstructure abnormalities in non-NPSLE patients.
作者
张鹏
夏建国
周文苏
孙中茹
李瑗
邹红梅
ZHANG Peng;XIA Jian-guo;ZHOU Wen-su;SUN Zhong-ru;LI Yuan(Graduate School of Dalian Medical University,Dalian 116044,LiaoningProvince,China;Taizhou People's Hospital Affiliated to Nanjing Medical University,Taizhou 225300,Jiangsu Province,China)
出处
《中国CT和MRI杂志》
2023年第6期31-33,共3页
Chinese Journal of CT and MRI
基金
江苏省卫健委科研课题(H2018093)
江苏省第五期“333工程”科研项目(BRA2017175)。
关键词
弥散张量成像
非神经精神性系统性红斑狼疮
各项异性分数
Diffusion Tensor Imaging
Non-Neuropsychiatric Systemic Lupus Erythematosus
Fractional Anisotropy
