摘要
目的调查深圳部分地区近4年的女性人乳头瘤病毒(HPV)的感染现状及各亚型分布情况,为宫颈疾病防治提供即时、科学的临床依据。方法选取2020年1月至2023年12月在该院门诊、住院及体检科进行HPV检测的80642例女性为研究对象。通过PCR和DNA反向点杂交检测HPV感染。记录所有女性受检者HPV感染、感染亚型、多重感染以及不同年龄感染情况。结果共检测HPV女性标本80642例,其中HPV阳性标本有14045例,阳性率17.42%。23种HPV基因型均被检出,各年龄组均以单一感染为主,占比13.06%,随着HPV感染型别的个数增多,各年龄阶段的感染人数在依次减少。≤24岁组HPV感染率最高,占34.18%。在高危型HPV感染中居前三位的是HPV52、HPV53、HPV16、HPV58(HPV16和HPV58感染率并列第三位)。2020年、2021年、2022年、2023年HPV感染率分别为23.42%、24.66%、24.11%、22.47%,2021年HPV总感染率最高,2023年HPV总感染率最低。结论本研究发现深圳地区女性HPV感染率较高,其中≤24岁年轻女性及高危型感染者需重点关注。主要高危亚型为HPV52、HPV53、HPV16和HPV58,提示应强化针对上述亚型的疫苗覆盖及精准筛查。本研究为宫颈癌防控提供了区域性循证依据,建议开展多中心流行病学研究以持续监测流行趋势。
Objective To investigate the infection status and genotype distribution of human papillomavirus(HPV)in women from Shenzhen in recent four years,and to provide scientific and immediate clinical basis for cervical disease prevention and treatment.Methods A total of 80,642 women who underwent HPV testing in the outpatient,inpatient and physical examination departments of the hospital from January 2020 to December 2023,and they were selected as the study objects.HPV infection was detected by polymerase chain(PCR)-reverse hybridization.All female HPV infection,infection subtypes,multiple infections and age-specific infections were recorded for.Results A total of 80642 female HPV specimens were detected,of which 14045 were HPV-positive,with a positive rate of 17.42%.All 23 kinds of HPV genotypes were detected,and the infection rate of HPV in≤24 years old was the highest,accounting for 34.18%.All age groups were mainly infected with a single infection,accounting for 13.06%.With the increase of the number of HPV infection types,the infected people at all ages decreased successively.The top three high-risk HPV types were HPV52,HPV53,HPV16,and HPV58(the infection rates of HPV16 and HPV58 were tied for third place).HPV infection rates in 2020,2021,2022 and 2023 were 23.42%,24.66%,24.11%and 22.47%,respectively.The total HPV infection rate was the highest in 2021 and the lowest in 2023.Conclusion In this study,we found that HPV infection rate was high among women in Shenzhen,and young women under 24 years of age and high-risk patients should be paid more attention to.The main high-risk subtypes were HPV52,HPV53,HPV16 and HPV58,suggesting that vaccine coverage and precise screening for these subtypes should be strengthened.This study provides a regional evidence-based basis for the prevention and control of cervical cancer and suggests that multicenter epidemiological studies should be conducted to continuously monitor the epidemic disease.
作者
黄霖
向琪
黄磊
钟小媚
张海燕
刘秀卿
HUANG Lin;XIANG Qi;HUANG Lei;ZHONG Xiaomei;ZHANG Haiyan;LIU Xiuqing(Department of Clinical Laboratory,the Second People's Hospital of Shenzhen,Shenzhen,Guangdong 518032,China)
出处
《检验医学与临床》
2025年第S1期1-5,共5页
Laboratory Medicine and Clinic
基金
广东省科技计划项目(2021A1515220084,2020B1111160001)。
关键词
人乳头瘤病毒
宫颈癌
筛查
年龄
human papillomavirus
cervical cancer
screening
age
