摘要
为探究近年来治疗缺血性脑卒中常用化痰方剂中化痰药的用药特点。以“化痰/祛痰/涤痰/豁痰/导痰/滚痰/半夏白术天麻汤/星蒌承气汤/温胆汤/二陈汤/小陷胸汤/羚角钩藤汤/解语丹”+“缺血性中风/缺血性脑卒中/脑缺血/脑梗死/脑梗塞/脑栓塞/脑血栓”+“临床”为主题词在中国知网(1986年5月1日—2024年4月1日)中进行高级检索,筛选出符合标准的文献,采用Excel和IBM SPSS Modeler 18.0软件对数据进行统计分析。化痰方剂中以半夏和天南星为缺血性脑卒中不同时期中使用频率最高的两味化痰药,其次为茯苓、石菖蒲、陈皮和甘草等;大多数化痰药的高频使用剂量在均在10~15 g。在四气五味统计中,缺血性脑卒中不同时期化痰药均以温、平、辛、苦、甘出现频率最高;归经统计中,不同时期化痰药都以肺、脾经为主。在化痰方剂药味统计中,急性期和康复期均以由8~14味药组成的方剂最常见,约占各自总频数的82.51%和78.05%;关联规则分析中得到25个支持度较高的中药组合,以化痰熄风通络药和化痰活血祛风药等配伍较多;方剂基本都采用中药饮片汤剂煎煮服药方式,且多与西药联合应用。临床上治疗缺血性脑卒中的常用化痰方剂中化痰药以半夏和天南星为主,大部分化痰药物的使用剂量范围在10~15 g,常用化痰方剂味药数以8~14味为主,研究成果为化痰中药和化痰方剂在缺血性中风治疗中的应用和从痰论治缺血性中风研究发展提供一定的参考和临床数据支持。
In order to explore the medication characteristics of expectorants in the Huatan prescriptions commonly used in treating ischemic stroke recently.“Huatan/Qutan/Ditan/Huotan/Daotan/Guntan/Banxia Baizhu Tianma Decoction/Xinglou Chengqi Decoction/Wendan Decoction/Erchen Decoction/Xiao xianxiong Decoction/Lingjiao Gouteng Decoction/Jieyu Dan”+“ischemic stroke/cerebral ischemia/cerebral infarction/cerebral embolism/cerebral thrombus”+“clinical”as the main topic on the China National Knowledge Network(from May 1,1986 to April 1,2024)was used to investigate the medication characteristics of expectorants,and selected literature meeting the criteria.Statistical analysis of the data was performed using Excel and IBM SPSS Modeler 18.0 software.The results show that Banxia and Tian nan-xing are the most frequently used expectorants in different stages of ischemic stroke,followed by Fuling,Shi chang-pu,Chenpi,and Gancao.The dosages of most expectorants are 10~15 g.In the analysis of Siqi and five flavors,Wen,Ping,Xin,Ku,and Gan have the highest frequency of occurrence in different stages of ischemic stroke.In the analysis of meridian tropism,the lung and spleen meridian have the highest frequency of occurrence.Most Huatan prescriptions are composed of 8~14 herbs in both the acute and rehabilitation stages,accounting for 82.51%and 78.05%of the total frequency,respectively.In the analysis of association rules,25 traditional Chinese medicine combinations with strong correlation strength are obtained,and the most combinations of herbs are Huatan-Xifeng-Tongluo and Huatan-Huoxue-Qufeng.Most Huatan prescriptions are administered through the traditional decoction method and generally used in combination with Western medicine.It is concluded that the commonly used expectorants in Huatan prescriptions for treating ischemic stroke are mainly Banxia and Tian nan-xing,and the dosage ranges of most expectorants are 10~15 g.The number of herbs in Huatan prescriptions is mainly 8~14.The research results provide references and clinical data support for the application of expectorant Chinese medicine and Huatan prescriptions in the treatment of ischemic stroke and the development of research on treating ischemic stroke from the perspective of phlegm.
作者
李洵
井卫朋
方晓艳
李艳
苗明三
LI Xun;JING Wei-peng;FANG Xiao-yan;LI Yan;MIAO Ming-san(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Zhengzhou 450046,China)
出处
《科学技术与工程》
北大核心
2025年第20期8435-8444,共10页
Science Technology and Engineering
基金
河南省重大公益专项(201300310100)
河南省重大科技专项(221100310400)
岐黄学者(国中医药人教函2022-6)。
关键词
临床数据挖掘
缺血性中风
化痰方剂
药味数量
化痰药
使用频率
剂量范围
药性归经
clinical data mining
ischemic stroke
Huatan prescriptions
number of medications
expectorants
usage frequency
dose range
drug properties
