摘要
目的:运用线栓制作脑缺血再灌注大鼠模型,观察黄芪总皂苷和三七总皂苷配伍对脑梗塞百分率的影响。方法及结果:应用二因素五水平均匀设计方法,观察到黄芪总皂苷16 mg/kg和三七总皂苷40 mg/kg配伍时,抗脑梗死形成作用最佳,2×2析因设计试验发现该剂量下两药配伍对于大鼠脑梗死有相加的保护作用。结论:黄芪总皂苷和三七总皂苷配伍具有协同的抗脑梗死作用。
Objective:To investigate the interactions between astragalosides(AS) and total saponins of Pnanx notoginseng(SPN) with various dosage.Methods:The model of focal cerebral ischemia by suture method in rats was used( ) in the study.The results were analysed with two statistics.Results:AS and SPN showed antiischemia effect.The compatible application of AS with dose of 16 mg/kg and SPN with dose of 40 mg/kg indicated more significant anti-ischemia action.Conclusion: The compatible application of AS and SPN related in a synergistic effect of anti-ischemia.
出处
《中国实验方剂学杂志》
CAS
2006年第12期56-58,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
黄芪总皂苷
三七总皂苷
抗脑缺血
协同作用
Astragalosides
Saponins of Pnanx notoginseng
Anti-ischemia
Synergistic effect
