摘要
目的了解注射用纳米制剂的研究进展,为其进一步开发提供参考和新思路。方法通过检索PubMed、Web of Science等数据库,筛选近20年发表的相关文献,对注射用纳米制剂的研究进展进行综述。结果临床常用的注射用纳米制剂包括脂质体、聚合物纳米粒、纳米晶,主要用于肿瘤、感染、精神分裂症的治疗,同时还可用于造影检查。目前,纳米制剂受到医药界的广泛关注和重视,注射用纳米药物因其长效、缓释、靶向等优点,在临床受到密切关注。结论近年来,注射用纳米药物的发展成为新型药物递送系统研发的热点。
Objective In order to understand the advances of injectable nanomedicines and provide a reference for research and development.Methods A comprehensive review of the literature was conducted by searching databases such as PubMed and Web of Science,selecting relevant publications from the past 20 years on injectable nanomedicines.Results Clinically used injectable nanomedicines include liposomes,polymers,iron oxide nanoparticles,and nanocrystals.These are primarily used for the treatment of cancer,infections,and schizophrenia,as well as for imaging diagnostics.Currently,nanomedicines are receiving widespread attention in the pharmaceutical industry.Injectable nanomedicines has been pained close attention in clinical practice,because of the advantages of prolonged release,sustained release,and targeting delivery.Conclusion In recent years,the development of injectable nanomedicines become a region attractive to the research and development of novel drug delivery systems.
作者
孙汝岚
刘干莎
杨倩
郑坤
孙春燕
谢攀
SUN Rulan;LIU Gansha;YANG Qian;ZHENG Kun;SUN Chunyan;XIE Pan(School of Bioscience and Technology,Chengdu Medical College,Chengdu 610500,China;Irradiation Preservation and Effect Key Laboratory of Sichuan Province,Chengdu 610101,China;The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)
出处
《西北药学杂志》
2025年第4期274-284,共11页
Northwest Pharmaceutical Journal
基金
四川省自然科学基金重点项目(编号:2024NSFSC0044)
成都医学院大学生创新创业训练计划项目(编号:202313705020)。
关键词
纳米制剂
脂质体纳米粒
聚合物纳米粒
纳米晶
nanomedicines
lipid nanoparticles
polymeric nanoparticles
nanocrystals
