摘要
目的探讨枯草杆菌二联活菌联合瑞巴派特治疗幽门螺杆菌(Helicobacter pylori,HP)阳性消化性溃疡(peptic ulcer,PU)对溃疡愈合、胃泌素及肠道菌群的影响。方法选取2021年8月—2023年8月HP阳性PU患者160例作为研究对象,用随机数字表法分为对照组和观察组,每组80例。2组均给予常规治疗,对照组在此基础上给予瑞巴派特治疗,观察组在此基础上给予枯草杆菌二联活菌联合瑞巴派特治疗。比较2组的治疗效果,HP根除率,溃疡愈合情况,治疗前后的消化相关因子[胃泌素(gastrin,GAS)、胃蛋白酶原Ⅰ(pepsinogenⅠ,PGⅠ)、胃蛋白酶原Ⅱ(pepsinogen Ⅱ,PGⅡ)]、肠道菌群、炎性因子[C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)]及不良反应的发生情况。结果观察组的总有效率、HP根除率均高于对照组(P<0.05);治疗2周后2组的溃疡黏膜形态结构、中性黏液、炎性细胞浸润程度评分,血清GAS、PGⅠ、PGⅡ、CRP、TNF-α、IL-6水平均低于治疗前,且观察组均低于对照组(P<0.05);2组治疗2周后的葡萄球菌、肠球菌数量均低于治疗前,且观察组均低于对照组,乳酸杆菌、拟杆菌、双歧杆菌数量均高于治疗前,且观察组均高于对照组(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论枯草杆菌二联活菌联合瑞巴派特治疗HP阳性PU能提高疗效,促进溃疡愈合,还能调节胃泌素水平和肠道菌群,减轻炎症反应,且安全性良好。
Objective To investigate the effects of Bacillus subtilis bifidobacterium combined with rebamipide on ulcer healing,gastrin,and intestinal flora in patients with Helicobacter pylori(HP)-positive peptic ulcer(PU).Methods A total of 160 patients with HP-positive PU in our hospital from August 2021 to August 2023 were selected and assigned to the 2 groups according to random number table method,80 patients in each group.Both groups were given conventional treatment.The control group was given rebabapide,while the observation group was given Bacillus subtilis bifidobacterium combined with rebabapide.The treatment effect and HP eradication rate of the 2 groups were compared,as well as ulcer healing,digestion-related factors[gastrin(GAS),pepsinogen Ⅰ(PGⅠ),and pepsinogen Ⅱ(PGⅡ)],intestinal flora,inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)]before and after treatment,and adverse reactions of the 2 groups were also compared.Results The total effective rate and HP eradication rate in the observation group were higher than those in the control group(P<0.05).After 2 weeks of treatment,the scores of ulcer mucosal morphology,neutral mucus,inflammatory cell infiltration,serum levels of GAS,PGⅠ,PGⅡ,CRP,TNF-α,and IL-6 in the 2 groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05);after 2 weeks of treatment,the number of Staphylococci and Enterococci in the 2 groups was lower than before treatment,with the observation group being lower than the control group.The number of Lactobacilli,Bacteroides,and Bifidobacteria was higher than before treatment,with the observation group being higher than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the the 2 groups(P>0.05).Conclusion The combination of Bacillus subtilis bifidobacterium and rebabapide in the treatment of HP-positive PU can improve the curative effect,promote ulcer healing,regulate gastrin and intestinal flora,reduce inflammation,and have good safety.
作者
崔红霞
韩爱娜
侯小霞
崔英
CUI Hongxia;HAN Aina;HOU Xiaoxia;CUI Ying(Department of Gastroenterology,Qingdao Jiaozhou Central Hospital,Qingdao 266300,China;Department of Pharmacy,Qingdao Jiaozhou Central Hospital,Qingdao 266300,China;Department of Obstetrics,Qingdao Jiaozhou Central Hospital,Qingdao 266300,China)
出处
《西北药学杂志》
2025年第4期138-144,共7页
Northwest Pharmaceutical Journal
基金
2022—2024年青岛市市级临床重点专科胃肠道肿瘤综合治疗专科资助项目。
