摘要
目的探讨薄层液基细胞学检测(thinprep liquid-based cytology test,TCT)、人乳头瘤病毒(human papillomavirus,HPV)-DNA检查及阴道镜在门诊宫颈癌筛查中的作用。方法选取2019年2月至2022年2月景德镇市妇幼保健院门诊检查的100例疑似宫颈癌患者作为研究对象,均接受TCT、HPV-DNA及阴道镜检查。比较TCT、HPV-DNA及阴道镜检查结果,以病理诊断结果为金标准,分析TCT、HPV-DNA、阴道镜检查单独及联合检测的诊断效能。结果病理诊断结果显示,阴性61例,阳性39例;TCT检查结果显示,阴性82例,阳性18例;HPV-DNA检查结果显示,阴性65例,阳性35例;阴道镜检查结果显示,阴性63例,阳性37例。HPV-DNA与阴道镜检查阳性率均高于TCT检查,差异有统计学意义(P<0.017)。联合检测的灵敏度高于TCT及HPV-DNA检查,准确度高于TCT、HPV-DNA及阴道镜检查,TCT检查的特异度高于HPV-DNA、阴道镜检查,阴道镜检查的灵敏度高于TCT,差异有统计学意义(P<0.008)。结论门诊宫颈癌筛查中联合应用TCT、HPV-DNA、阴道镜检查效果更好,能明显提高宫颈病变检出率。
Objective To explore the role of liquid-based cytology test(TCT),human papillomavirus(HPV)-DNA testing and colposcopy in outpatient cervical cancer screening.Methods 100 suspected cervical cancer patients who underwent outpatient examinations at Jingdezhen Maternal and Child Health Hospital from February 2019 to February 2022 were selected as the research subjects,all patients underwent TCT,HPV-DNA and colposcopy examination.The results of TCT,HPV-DNA and colposcopy were compared,took the pathological diagnosis results as the gold standard,the diagnostic efficacy of TCT,HPV-DNA,colposcopy examination single and combined were analysed.Results Pathological diagnosis showed that 61 cases were negative and 39 cases were positive;TCT examination showed that 82 cases were negative,18 cases were positive;HPV-DNA examination showed that 35 cases were positive,65 cases were negative;colposcopy examination showed that 37 cases were positive,63 cases were negative.The positive rates of HPV-DNA and colposcopy were higher than that of TCT,and the differences were statistically significant(P<0.017).The sensitivity of the combined examination was higher than that of TCT and HPV-DNA examination,and the accuracy was higher than that of TCT,HPV-DNA and colposcopy examination,the specificity of TCT was higher than that of HPV-DNA and colposcopy examination,the sensitivity of colposcopy examination was higher than that of TCT examination,and the differences were statistically significant(P<0.008).Conclusion The combined application of TCT,HPV-DNA and colposcopy in outpatient cervical cancer screening is better,and can significantly improve the detection rate of cervical lesions.
作者
王方
何丹
黄姗
WANG Fang;HE Dan;HUANG Shan(Department of Gynecology,Jingdezhen Maternal and Child Health Hospital,Jingdezhen,Jiangxi,333000,China)
出处
《当代医学》
2024年第35期143-146,共4页
Contemporary Medicine
关键词
宫颈癌
人乳头瘤病毒
液基细胞学检查
阴道镜检查
Cervical cancer
Human papillomavirus
Thinprep liquid-based cytology test
Vaginoscope
