摘要
酒精性肝病(Alcoholic liver disease,ALD)是长期大量饮酒导致的肝脏类疾病,也是肝脏相关发病死亡率最常见原因之一。中医认为,ALD的发生发展主要与酗酒有关,其病机演变是一个逐渐加重的过程,酒热伤肝,初期未出现明显的器质性病变,随疾病进展至不同阶段,内湿显现,湿郁化热,气滞血瘀逐步加重,通过直接或间接影响各脏腑间功能,形成肝脏与其他器官之间串扰的复杂机制,由此导致病理状态下的多器官功能障碍。现代研究发现,长期酗酒不仅会对肝脏造成直接损伤,还能通过改变肠道屏障功能和肠道微生物群落、产生肾损伤和心功能等方面影响,导致疾病进展到终末期肝病。本文结合酒精性肝病的中西医发病机制和器官串扰理论综述了近年来关于肝脏与其他器官之间相互影响的研究,介绍治疗酒精性肝病的潜在策略,为发现新的治疗途径提供参考。
Alcoholic liver disease(ALD)is a liver disease caused by long-term heavy drinking and one of the most common causes of liver-related morbidity and mortality.According to Chinese medicine,the development of ALD is mainly related to alcoholism,and the evolution of its pathology is a gradually aggravating process.Wine-heat injures the liver,without obvious organic lesions at the initial stage,and as the disease progresses to different stages,internal dampness appears,dampness depresses and transforms into heat,and Qi stagnation and blood stasis are gradually aggravated,which affects the functions of various internal organs,directly or indirectly,and creates a complex mechanism of crosstalk between the liver and other organs,which leads to the pathological condition of This leads to the pathological state of multi-organ dysfunction.Modern research has found that long-term alcohol abuse not only causes direct damage to the liver,but also leads to progression to end-stage liver disease by altering the intestinal barrier function and intestinal microbial community,and producing kidney damage and cardiac function.This article reviewed recent studies on the interactions between the liver and other organs in light of the Chinese and Western pathogenesis of alcoholic liver disease and the theory of organ crosstalk,and introduces potential strategies for the treatment of alcoholic liver disease,which will provide a reference for the discovery of new therapeutic avenues.
作者
董丽敏
王平
王仪
姚晓东
丁志平
张茹
DONG Limin;WANG Ping;WANG Yi;YAO Xiaodong;DING Zhiping;ZHANG Ru(School of Pharmaceutical Sciences,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Academy of Chinese Medicine,Jinan 250014,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)
出处
《世界科学技术-中医药现代化》
北大核心
2025年第6期1522-1529,共8页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
山东大学科学技术局山东大学“新高校20条”资助项目科研带头人工作室(202228121):山东道地中药材抗病毒研究科研带头人工作室,负责人:王平
山东省科学技术厅山东省重点研发计划重大科技创新工程(2021SFGC1205):药食同源特色产品创新研发与应用示范,负责人:王平
国家中医药管理局科技司省部级科技项目(GZY-KJS-2023-027):复方黄柏液涂剂作用机理解析,负责人:王平。
关键词
酒精性肝病
器官串扰
藏象学说
Alcoholic liver disease
Inter-organ cross-talk
Zangxiang theory
