摘要
牙源性间充质干细胞(DMSC)因自我更新和多向分化潜能,在口腔组织再生领域展现出广阔的应用前景。线粒体作为细胞的重要细胞器,不仅负责能量代谢,还通过调控细胞代谢、细胞凋亡和信号转导等方式影响干细胞的干性维持和分化方向。近年来,线粒体在DMSC成骨分化和成牙分化过程中的作用机制逐渐成为研究热点。本文综述了线粒体在DMSC成骨及成牙分化中的调控机制,重点阐述了线粒体能量代谢(氧化磷酸化与糖酵解)和质量控制[生物发生、动力学(分裂与融合)、自噬]对DMSC成骨分化和成牙分化的调控作用,旨在为牙再生、牙周组织再生等口腔组织工程的研究和应用提供理论依据和参考。
Dental-derived mesenchymal stem cells(DMSC),owing to their self-renewal capacity and multi-lineage differentiation potential,have demonstrated significant promise in the field of oral tissue regeneration.Mitochondria,as essential organelles within cells,can not only be responsible for energy metabolism but also influence the maintenance of stem cell stemness and the direction of differentiation by regulating cellular metabolic processes,apoptosis,and signal transduction pathways.In recent years,the mechanisms by which mitochondria participating in the osteogenic and odontogenic differentiation of DMSC have gradually become a research focus.This paper reviews the regulatory mechanisms of mitochondria in the osteogenic and odontogenic differentiation of DMSC,with emphasis on how mitochondrial energy metabolism(oxidative phosphorylation and glycolysis)and quality control processes(namely biogenesis,dynamics as fission and fusion,and autophagy)modulate the differentiation of DMSC.The aim is to provide a theoretical basis and reference for the research and application of dental pulp regeneration,periodontal tissue regeneration,and other aspects of oral tissue engineering.
作者
王俐捷
周建
周陈晨
Wang Lijie;Zhou Jian;Zhou Chenchen(Department of Pediatric Dentistry,West China Hospital of Stomatology,Sichuan University & State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases,Chengdu 610041,China;Department of VIP Dental Service,Capital Medical University School of Stomatology,Beijing 100070,China)
出处
《中华口腔医学杂志》
北大核心
2025年第6期662-668,共7页
Chinese Journal of Stomatology
基金
国家自然科学基金(82171001,82222015)。
关键词
线粒体
牙源性间充质干细胞
成骨分化
成牙分化
口腔组织再生
Mitochondrial
Dental-derived mesenchymal stem cells
Osteogenic differentiation
Odontogenic differentiation
Oral tissue regeneration
