摘要
中医药是中华民族的瑰宝,蕴藏着丰富多样的化学成分,展现出独特的药理活性,且在临床应用中彰显出重要价值,深邃的内涵和广阔的应用前景亟待进一步深入挖掘与系统研究。葛根素是一种从豆科葛属植物中提取的天然异黄酮类碳苷小分子成分,也是药食同源中药葛根的主要活性成分,具有降血压、抗动脉粥样硬化、抗缺血再灌注损伤、抗血栓、抗炎、抗肿瘤、保护肝脏、保护神经细胞、调节肠道微生物群等多种药理作用,也是当前研究较多的热点活性成分。该文详细综述了历年来葛根素的作用机制,以期为葛根素的深入研发和临床应用提供借鉴及理论参考。
Traditional Chinese medicine(TCM),a treasure of the Chinese nation,contains abundant chemical components and demonstrates unique pharmacological activities,showing important values in clinical applications.With profound connotations and broad application prospects,TCM urgently needs us to further explore and conduct systematic research.Puerarin is a small-molecule natural isoflavonoid carbon glycoside extracted from plants of Pueraria.It is also the main active ingredient of Puerariae Lobata Radix,a Chinese herbal medicine with both medicinal and edible values.Puerarin has a variety of pharmacological effects such as blood pressure-lowering,anti-atherosclerosis,anti-ischemia-reperfusion injury,antithrombotic,anti-tumor,anti-inflammatory,liver-protecting,nerve cell-protecting,and intestinal microbiota-regulating effects.It is also an active ingredient that has been widely studied.This article comprehensively reviews the research progress in the pharmacological effects and molecular mechanisms of puerarin over the years,aiming to provide references and theoretical support for the in-depth research and development as well as clinical application of puerarin.
作者
孟晓伟
郭风梅
王倩倩
李家荣
张妮
屈飞
刘荣华
朱卫丰
MENG Xiao-wei;CUO Feng-mei;WANG Qian-qan;LI Jia-rong;ZHANG Ni;QU Fei;LIU Rong-hua;ZHU Wei-feng(Jiangxi University of Chinese Medicine,Nanchang 330004,China;Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine,Jiangxi University of Chinese Medicine,Nanchang 330004,China)
出处
《中国中药杂志》
北大核心
2025年第11期2954-2968,共15页
China Journal of Chinese Materia Medica
基金
江西省自然科学基金项目(20242BAB22010)
江西省重点研发计划“揭榜挂帅”项目(20223BBG71002)
江西省科技创新基地项目(2024SSY07102)
国家重点研发计划项目(2017YFC1702902)。
关键词
葛根
葛根素
药理作用
作用机制
研究进展
Puerariae Lobate Radix
puerarin
pharmacological effect
mechanism
research progress
