摘要
【目的】探讨功能性碳水化合物(FCs)对非酒精性脂肪性肝病(NAFLD)患者肝功能、胰岛素抵抗及生活质量的影响。【方法】选择2022年6月至2023年6月本院收治的128例NAFLD患者,根据随机数字表法将患者分为观察组(n=66)和对照组(n=62)。对照组患者按照常规NAFLD治疗方案进行治疗,观察组在对照组基础上给予FCs饮食干预,两组均干预6个月。比较两组患者胰岛素抵抗指数(HOMA-IR)、血脂水平、生活质量以及肝功能指标。【结果】干预后,两组患者HOMA-IR、空腹血糖(FPG)、糖化血红蛋白(HbA1c)均低于干预前,且观察组低于对照组,差异有统计学意义(P<0.05)。干预后,两组甘油三酯(TG)、总胆固醇(TC)水平低于干预前,且观察组低于对照组,差异有统计学意义(P<0.05)。干预后,观察组天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)以及γ-谷氨酰转移酶(GGT)均低于干预前,对照组GGT均低于干预前(P<0.05);观察组AST、ALT、GGT均低于对照组(P<0.05)。干预后,观察组生理功能、总体健康、生理职能评分高于干预前,且高于对照组,差异有统计学意义(P<0.05)。干预后,对照组肝脏硬度值(LSM)、受控衰减参数(CAP)与干预前比较,差异无统计学意义(P>0.05);观察组LSM、CAP均低于干预前,且低于对照组,差异有统计学意义(P<0.05)。【结论】FCs可有效改善NAFLD患者胰岛素抵抗及肝功能,提高患者生活质量,有助于缓解患者肝脏脂肪堆积情况,值得临床借鉴。
【Objective】To explore the effect of functional carbohydrates(FCs)on liver function,insulin resistance and quality of life in patients with non-alcoholic fatty liver disease(NAFLD).【Methods】A total of 128 NAFLD patients admitted to our hospital from June 2022 to June 2023 were selected and divided into the observation group(n=66)and the control group(n=62)by random number table method.The control group was treated with conventional NAFLD treatment regimen,and the observation group was given FCs dietary intervention on the basis of the control group.Both groups were intervened for 6 months.The changes of insulin resistance(HOMA-IR),blood lipid levels,quality of life and liver function indexes were compared between the two groups.【Results】After intervention,HOMA-IR,fasting plasma glucose(FPG)and glycosylated hemoglobin(HbA1c)in both groups were lower than those before intervention,and the observation group was lower than the control group,with statistically significant differences(P<0.05).After intervention,triglyceride(TG)and total cholesterol(TC)levels in both groups were lower than those before intervention,and the observation group was lower than the control group,with statistically significant differences(P<0.05).After intervention,aspartate aminotransferase(AST),alanine aminotransferase(ALT)and gamma-glutamyl transferase(GGT)in the observation group were lower than those before intervention,and GGT in the control group was lower than that before intervention(P<0.05);AST,ALT and GGT in the observation group were lower than those in the control group(P<0.05).After intervention,the scores of physical function,general health and physical function in the observation group were higher than those before intervention and higher than those in the control group,with statistically significant differences(P<0.05).After intervention,there was no significant difference in liver stiffness measurement(LSM)and controlled attenuation parameter(CAP)between the control group and those before intervention(P>0.05);LSM and CAP in the observation group were lower than those before intervention and lower than those in the control group,with statistically significant differences(P<0.05).【Conclusion】FCs can effectively improve insulin resistance and liver function in NAFLD patients,improve the quality of life of patients,and help alleviate the accumulation of liver fat,which is worthy of clinical reference.
作者
姚娟娟
田欣怡
李桂连
罗苇钰
YAO Juanjuan;TIAN Xinyi;LI Guilian(Zhuhai Integrated Traditional Chinese and Western Medicine Hospital,Zhuhai Guangdong 519020)
出处
《医学临床研究》
2025年第6期936-939,共4页
Journal of Clinical Research
基金
珠海市科技创新局医疗卫生项目(编号:2320004000183)。
关键词
非酒精性脂肪性肝病
碳水化合物
肝功能试验
胰岛素抵抗
生活质量
Non-alcoholic Fatty Liver Disease
Carbohydrates
Liver Function Tests
Insulin Resistance
Quality of Life
