摘要
目的探讨血清铁水平与肉芽肿性小叶性乳腺炎(GLM)的相关性。方法2022年5月~2023年5月收治的GLM病人102例。根据病人就诊时所处的病程阶段分为肿块期组(29例)、脓肿期组(48例)及缓解期组(25例),比较不同分期GLM病人的血清铁水平,采用Spearman相关分析血清铁水平与炎症性指标的相关性,并通过随访比较治疗缓解前后病人血清铁水平的变化。结果102例GLM病人均为女性,脓肿期组、肿块期组、缓解期组病人血清铁水平分别为12.8(10.20,17.50)μmol/L、12.8(10.20,17.50)μmol/L、15.4(13.65,18.50)μmol/L,其中脓肿期组低于肿块期组和缓解期组,差异有统计学意义(P<0.001)。双变量Spearman相关分析结果显示,血清铁水平与白细胞计数、中性粒细胞计数、中性粒细胞百分比呈中等强度负相关(r=-0.336,P=0.001;r=-0.361,P=0.001;r=-0.334,P<0.01),与单核细胞计数呈低等强度负相关(r=-0.214,P=0.031),与淋巴细胞百分比、白细胞介素(IL)-2、IL-4、IL-10水平呈中等强度正相关(r=0.328,P<0.01;r=0.494,P=0.023;r=0.514,P=0.017;r=0.478,P=0.028)。45例GLM随访病人经治疗缓解后血清铁水平高于缓解前血清铁水平[(15.09±4.78)μmol/L比(10.64±4.47)μmol/L,P<0.001]。结论血清铁水平与GLM的病情严重程度、多种免疫细胞和细胞因子等炎症性指标及病情转归相关。
Objective To explore the correlation between serum iron levels and granulomatous lobular mastitis(GLM).Methods A total of 102 patients with GLM were admitted from May 2022 to May 2023.According to the disease course stage at the time of the patients’visit,they were divided into the mass stage group(29 cases),the abscess stage group(48 cases),and the remission stage group(25 cases).Compare the serum iron levels of patients with GLM at different stages.Spearman correlation analysis was used to analyze the correlation between serum iron levels and inflammatory indicators,and the changes in serum iron levels of patients before and after treatment remission were compared through follow-up.Results All the 102 GLM patients were female.The serum iron levels of patients in the abscess stage group,the mass stage group and the remission stage group were 12.8(10.20,17.50)μmol/L,12.8(10.20,17.50)μmol/L and 15.4(13.65,18.50)μmol/L,respectively.The abscess stage group was lower than the mass stage group and the remission stage group,and the difference was statistically significant(P<0.001).The results of bivariate Spearman correlation analysis showed that the serum iron levels were moderately negatively correlated with white blood cell count,neutrophil count and the percentage of neutrophils(r=-0.336,P=0.001;r=-0.361,P=0.001;r=-0.334,P<0.01),low intensity negative correlation with monocyte count(r=-0.214,P=0.031),moderately positively correlated with the percentage of lymphocytes,the levels of interleukin(IL)-2,IL-4,IL-10(r=0.328,P<0.01;r=0.494,P=0.023;r=0.514,P=0.017;r=0.478,P=0.028).Serum iron levels in 45 GLM follow-up patients after treatment remission were higher than those before remission[(15.09±4.78)μmol/L vs.(10.64±4.47)μmol/L,P<0.001].Conclusion Serum iron level is associated with disease severity,inflammatory markers such as immune cells and cytokines,and disease outcome of GLM.
作者
李银鑫
郑碧连
陈创
孙圣荣
LI Yinxin;ZHENG Bilian;CHEN Chuang;SUN Shengrong(Department of Breast and Thyroid Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《临床外科杂志》
2025年第6期588-591,共4页
Journal of Clinical Surgery
基金
湖北省自然科学基金面上项目(2023AFB701)
武汉大学人民医院交叉创新人才项目(JCRCFZ-2022-015)。
