摘要
目的探索我国18个长寿地区65岁及以上老年人瘦体重(LBM)、瘦体重指数(LBMI)、脂肪量(FM)及脂肪量指数(FMI)与抑郁症状的关系。方法横断面研究。研究对象来自中国老年健康生物标志物队列,纳入65岁及以上老年人。收集人口学特征、生活方式、身体功能状态及病史信息,采用患者健康问卷-9(PHQ-9)评估抑郁症状,测量LBM和FM,并计算LBMI及FMI。根据PHQ-9总分是否≥10分将研究对象分为抑郁组和无抑郁组,比较两组间LMB、LBMI、FM及FMI差异。采用限制性立方样条绘制LMB、LBMI、FM及FMI与存在抑郁症状的暴露-反应关系曲线。分别根据LBM、LBMI、FM及FMI的三分位数将研究对象划分为低、中、高三组,并通过多因素logistic回归探讨LMB、LBMI、FM及FMI与抑郁症状的关联。结果共纳入4246名老年人,年龄(81.8±10.2)岁,男2034名(47.9%)。无抑郁组4008名,年龄(81.9±10.2)岁,男1957名(48.8%);抑郁组238名,年龄(80.8±9.6)岁,男77名(32.4%)。抑郁组LBM低于无抑郁组[(36.8±6.8)kg比(39.0±7.5)kg,P<0.001]。限制性立方样条回归模型显示,LBM、LBMI、FM及FMI与存在抑郁症状间无非线性暴露-反应关系(均P>0.05)。多因素logistic回归模型分析显示,LBM及LBMI与抑郁风险呈负相关(均P<0.05)。与低LBM或低LBMI组相比,高LBM组(OR=0.458,95%CI:0.291~0.715)和高LBMI组(OR=0.646,95%CI:0.442~0.939)存在抑郁症状的概率更低。FM及FMI与抑郁症状之间无明显关联(均P>0.05)。结论中国长寿地区65岁及以上老年人的LBM和LBMI与抑郁风险呈负向关联。
Objective To explore the association of lean body mass(LBM),lean body mass index(LBMI),fat mass(FM)and fat mass index(FMI)with depressive symptoms in adults aged 65 and above in 18 longevity areas in China.MethodsA cross-sectional study.The study participants were from the Chinese Longitudinal Healthy Longevity Biomarker Cohort Study,comprising elderly individuals aged 65 years and above.Demographic characteristics,lifestyle factors,physical function status,and disease history were collected.Depressive symptoms were assessed using the 9-item Patient Health Questionnaire(PHQ-9).LBM and FM were measured to calculate LBMI and FMI,respectively.Participants were categorized into the depressive group and non-depressive group based on whether the PHQ-9 score≥10 points,and the differences in LBM,LBMI,FM,and FMI between the two groups were compared.Restricted cubic spline models were used to illustrate exposure-response relationships between LBM,LBMI,FM,FMI and the presence of depressive symptoms.Participants were categorized into low,moderate,and high groups based on the tertiles of LBM,LBMI,FM and FMI,respectively,and multivariable logistic regressions were applied to examine the associations of LBM,LBMI,FM,and FMI with depressive symptoms.ResultsA total of 4246 older adults were included,with 2034 males(47.9%)and a mean age of(81.8±10.2)years.In the non-depressive group(n=4008),the mean age was(81.9±10.2)years,with 1957 males(48.8%).In the depressive group(n=238),the mean age was(80.8±9.6)years,with 77 males(32.4%).The LBM of the depvessive group was lower than that of the non-depressive group[(36.8±6.8)kg vs(39.0±7.5)kg,P<0.001].Restricted cubic spline analysis indicated no non-linear exposure-response relationships between LBM,LBMI,FM,FMI,and the presence of depressive symptoms(all P>0.05).Multifactor logistic regression analysis showed that LBM and LBMI were negatively associated with the risk of depression(all P<0.05).Compared with the low LBM(or LBMI)group,the high LBM group(OR=0.458,95%CI:0.291-0.715)and the high LBMI group(OR=0.646,95%CI:0.442-0.939)had a lower likelihood of experiencing depressive symptoms.No statistically significant associations were found between FM,FMI,and depressive symptoms(all P>0.05).ConclusionAmong adults aged 65 years and above in longevity regions of China,higher LBM and LBMI are negatively associated with the risk of depressive symptoms.
作者
刘思馨
齐力
陈晨
谭纯
钱豪
戴向龙
杨淋森
张曾航
朱子月
孟熙
许梓楠
胡雪华
张振伟
王君
周锦辉
石文惠
李志浩
施小明
毛琛
吕跃斌
Liu Sixin;Qi Li;Chen Chen;Tan Chun;Qian Hao;Dai Xianglong;Yang Linsen;Zhang Zenghang;Zhu Ziyue;Meng Xi;Xu Zinan;Hu Xuehua;Zhang Zhenwei;Wang Jun;Zhou Jinhui;Shi Wenhui;Li Zhihao;Shi Xiaoming;Mao Chen;Lyu Yuebin(Department of Epidemiology,School of Public Health,Southern Medical University,Guangzhou 510515,China;China CDC Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China;Beijing Center for Disease Control and Prevention,Beijing 100020,China;School of Public Health,Anhui Medical University,Hefei 230032,China;School of Public Health,Jilin University,Changchun 130012,China;National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《中华医学杂志》
北大核心
2025年第22期1840-1846,共7页
National Medical Journal of China
基金
国家自然科学基金(82025030,82222063,82230111)
国家重点研发计划(2023YFC2603401)。
关键词
老年人
瘦体重
脂肪量
抑郁症状
横断面研究
Aged
Lean body mass
Fat mass
Depressive symptom
Cross-sectional study
