摘要
骨筋膜室综合征(Osteofascial compartment syndrome,OCS)是好发于骨伤科的严重并发症,治疗延误会造成肢体不可逆损伤。现代交通外伤事故频发,OCS的发病率和病残风险呈现上升趋势,因此引起医学界的广泛关注。本文基于OCS中西医临床病症特点,通过查阅知网(CNKI)、PubMed等数据库中的相关文献,对目前常用的OCS动物模型进行总结,结合临床诊断标准,对动物模型吻合度进行数据评价,分析模型综合特点,为现代中西医治疗OCS提供参考价值。研究发现,目前OCS模型制备最常用的是家兔模型,主要通过压力损伤的方式进行造模。然而,当前使用的造模方法多是国外研究所提供,而针对OCS中西医结合治疗的病症结合模型尚缺乏研究,这在一定程度上限制了疾病研究的深入展开,因此本研究通过大量文献分析,归纳总结OCS现存模型的优缺点,结合中西医基础理论,为OCS中西医病证结合模型的制备提出建议。
Osteofascial compartment syndrome(OCS)is a serious complication frequently occurring in the orthopedic department,and delayed treatment may result in irreversible limb damage.With the increase of traffic trauma accidents in modern times,the incidence and disability risk of OCS have increased,so it has been widely concerned by medicine.Based on the clinical characteristics of OCS in traditional Chinese and Western medicine,this paper summarized the commonly used animal models of OCS by referring to CNKI and PubMed literature,and evaluated the data of the animal models′coincidence in combination with clinical diagnostic criteria,analyzed the comprehensive characteristics of the models,and provided a feasible reference for the animal models in the treatment of OCS in modern traditional Chinese and Western medicine.The results showed that the most commonly used OCS model was the rabbit model,which was constructed with pressure damage.Most of the methods are provided by foreign research institutes,but there is no research on the model of combining disease and syndrome of OCS with traditional Chinese and Western medicine,which brings certain obstacles to disease research.Therefore,this study summarized the advantages and disadvantages of the existing model of OCS through a large number of literature analysis,and put forward suggestions for the preparation of the model of combining traditional Chinese and Western medicine with fundamental theories of traditional Chinese and Western medicine.
作者
刘雨倩
王嘉
张路锦
朱飞鹏
苗明三
LIU Yuqian;WANG Jia;ZHANG Lujin;ZHU Feipeng;MIAO Mingsan(Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Zhengzhou 450046,China)
出处
《世界科学技术-中医药现代化》
北大核心
2025年第3期809-814,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
河南省重大专项(221100310400):基于“核心功效-生物活性-物质基础”的八大宛药质量标准体系建立,负责人:苗明三
河南省国际合作重点项目(231111521200):豫药外用防治免疫性疾病的现代研究,负责人:苗明三
国家中医药管理局联合开放课题(GZYKJS-2022-040-1):仲景经方保健中药功能评价与应用示范,负责人:苗明三。
关键词
骨筋膜室综合征
动物模型
吻合度分析
指标评价
Osteofascial compartment syndrome
Animal model
Anastomosis analysis
Index evaluation
