摘要
目的分析乳头状甲状腺癌(PTC)BRAF V600E突变与中央区淋巴结转移的关系。方法选取本院行手术治疗的PTC患者381例为研究对象,根据术前BRAF V600E突变检测结果将其分为BRAF V600E突变阳性组和阴性组。比较两组中央区淋巴结转移情况及临床病理特征。结果BRAF V600E突变阳性率为58.0%(221/381)。BRAF V600E突变阳性组中央区淋巴结转移率高于阴性组(P<0.05)。BRAF V600E突变阳性组男性、多病灶数目、病灶直径>1 cm、双侧病灶分布、被膜侵犯占比高于阴性组(P<0.05)。结论PTC患者BRAF V600E突变阳性与中央区淋巴结转移有密切关系,可为手术决策提供参考。
Aim To analyze the relationship between BRAF V600E mutation and central lymph node metastasis in papillary thyroid cancer(PTC).Methods 381 PTC patients who underwent surgical treatment in our hospital were selected as the research subjects.Based on the preoperative BRAF V600E mutation detection results,they were divided into a BRAF V600E mutation positive group and a negative group.The central lymph node metastasis and clinical pathological characteristics between two groups were compared.Results The positive rate of BRAF V600E mutation was 58.0%(221/381).The central lymph node metastasis rate in the BRAF(v600E)mutation positive group was higher than that in the negative group(P<0.05).The BRAF V600E mutation-positive group had higher proportions of males,multiple lesions,lesion diameter>1 cm,bilateral lesion distribution,and capsular invasion compared to the negative group(P<0.05).Conclusion The positive BRAF V600E mutation in PTC patients is closely related to central lymph node metastasis,which can provide reference for surgical decision-making.
作者
胡成
王佑权
HU Cheng;WANG Youquan(Department of Thyroid and Breast Surgery,Longhua District People's Hospital,Shenzhen 518000,Guangdong,China)
出处
《中南医学科学杂志》
2025年第4期739-741,共3页
Medical Science Journal of Central South China
基金
深圳市龙华区医疗卫生机构区级科研项目(2023031)。
