摘要
目的探讨血管紧张素原(angiotensinogen,AGT)、血管紧张素转换酶(angiotensin-converting enzyme,ACE)及AngⅡ受体(AngII receptor,ATR)基因多态性联合气候因素对甘南地区藏族人群原发性高血压(EH)发病率的影响。方法采用随访研究,选择2019年4月于兰州大学第二医院健康管理中心体检并同意入组的甘南地区藏族人群作为固定队列,随访3.5年后测量入组对象血压值。同时,收集所有研究对象外周血使用基因芯片技术检测血管紧张素原(AGT)、血管紧张素转换酶(ACE)及AngⅡ受体(ATR)基因多态性位点,使用logistic回归模型和叉生法以及多因子降维(multifactor-dimensionality reduction,MDR)分析可能存在的交互作用。结果日照时间为甘南藏族地区人群高血压发病的保护因素(OR=0.781),而相对湿度(OR=1.182)、气压(OR=1.338)及温度(OR=1.449)为高血压发病的危险因素。依据偏相关性分析结果,控制气压因素后,温度对于高血压发病无影响。高气压与AGT基因rs699(OR=1.650,95%CI:1.293~2.399,P<0.001)、rs5049(OR=1.711,95%CI:1.337~4.920,P<0.001)基因多态性存在相加交互作用,相对湿度与AGT基因rs699(OR=0.472,95%CI:0.120~0.783,P<0.05)基因多态性存在相乘交互作用,海拔≥3000m与AGT基因rs699(OR=1.503,95%CI:1.220~3.174,P<0.01)、rs5049(OR=1.673,95%CI:1.380~3.961,P<0.001)、rs2148582(OR=0.519,95%CI:0.284~0.716,P<0.05)基因多态性存在相乘交互作用,而气候因素与ACE、ATR基因多态性对高血压发病无交互作用。结论气候因素、海拔≥3000m与甘南藏族地区人群高血压发病密切相关,且AGT基因多态性与气候因素交互作用影响该地区人群高血压发病,应综合考虑基因与气候因素及时进行高血压防控。
Objective To investigate the effect of angiotensinogen(AGT),angiotensin-converting enzyme(ACE)and AngII receptor(ATR)gene polymorphisms combined with climatic factors on the incidence of essential hypertension(EH)in Tibetan population in Gannan area.Methods A follow-up study was conducted to select 671 Tibetan people in Gannan area who were physically examined in April 2019 at the Health Management Center of the Second Hospital of Lanzhou University and agreed to be enrolled as a fixed cohort,and the blood pressure values of the enrolled subjects were measured after 3.5 years of follow-up,and a total of 501 cases were obtained.At the same time,the peripheral blood of all subjects was collected and the polymorphisms of AGT,ACE and ATR genes were detected by gene chip technology,and the possible interactions were analyzed by logistic regression model,fork generation method and multifactor-dimensionality reduction(MDR).Results Sunshine time was a protective factor for the incidence of hypertension in the Tibetan population of Gannan(OR=0.781),while relative humidity(OR=1.182),air pressure(OR=1.338)and temperature(OR=1.449)were the risk factors for the incidence of hypertension.According to the results of partial correlation analysis,temperature had no effect on the incidence of hypertension after controlling air pressure.There was an additive interaction between high air pressure and the polymorphisms of rs699(OR=1.650,95%CI:1.293-2.399,P<0.001)and rs 5049(OR=1.711,95%CI:1.337-4.920,P<0.001)genes of AGT gene;there was a multiplicative interaction between relative humidity and rs699(OR=0.472,95%CI:0.120-0.783,P<0.05);there was a multiplicative interactions between the altitude≥3000 m and rs699(OR=1.503,95%CI:1.220-3.174,P<0.01),rs5049(OR=1.673,95%CI:1.380-3.961,P<0.001)or rs2148582(OR=0.519,95%CI:0.284-0.716,P<0.05).However,there was no interaction between climatic factors and ACE or ATR gene polymorphisms on the incidence of hypertension.Conclusion Climatic factors and altitude≥3000 m are closely related to the incidence of hypertension in the Tibetan population of Gannan area,and the interaction between AGT gene polymorphisms and climatic factors affects the incidence of hypertension in the population of this area.
作者
闫雯
陈睿迪
赵于飞
韩树珍
李兴杰
YAN Wen;CHEN Ruidi;ZHAO Yufei;HAN Shuzhen;LI Xingjie(Health Management Center,the Second Hospital of Lanzhou University,Lanzhou,Gansu 730000,China)
出处
《公共卫生与预防医学》
2025年第4期114-117,共4页
Journal of Public Health and Preventive Medicine
基金
甘肃省自然科学基金项目(23JRRA0993)
兰州大学第二医院萃英科技创新计划项目(CY2020-MS15)
兰州市科技计划项目(2020-ZD-89)。
