摘要
背景:种植体周围炎的发生发展与免疫炎症微环境密切相关,通过明确免疫炎症微环境作用机制来治疗种植体周围炎是目前重要的研究方向。目的:综述免疫炎症微环境在种植体周围炎中的作用机制及研究进展。方法:以“Peri-implantitis,bone integration,immune inflammatory microenvironment,microbiological profile,immune response mechanism,signaling pathway”为英文检索词,以“种植体周围炎,骨结合,免疫炎症微环境,微生物特征,免疫应答机制,信号通路”为中文检索词,分别在PubMed数据库和中国知网中进行文献检索,检索时限为各数据库建库时间至2024年9月。对筛选搜索到的文献进行分析、归纳和总结,最终对相关的79篇文献进行汇总。结果与结论:①种植体周围炎的发生和发展与复杂的微生物特性密切相关,刺激机体产生免疫炎症反应,加剧种植体周围骨吸收,在这一过程中信号通路起着重要的调节作用。受限于当前微生物培养和蛋白质组学等技术的发展,对种植体周围炎的微生物特性、免疫应答机制、信号通路等方面的认识还不够全面,因此,还需要对其进行大量的临床和基础研究。②根据种植体周围炎的免疫炎症微环境的特点,减少促炎因子的释放、调控相关信号通路、抑制牙槽骨吸收并促进新骨生成,有望成为预防和治疗种植体周围炎的有效策略。
BACKGROUND:The development of peri-implantitis is closely related to its immuno-inflammatory microenvironment,and the treatment of peri-implantitis by clarifying the mechanism of the immuno-inflammatory microenvironment is an important direction of research at present.OBJECTIVE:To review the mechanism and research progress of the immuno-inflammatory microenvironment in peri-implantitis.METHODS:“Peri-implantitis,bone integration,immune inflammatory microenvironment,microbiological profile,immune response mechanism,signaling pathway”were used as Chinese and English search terms.Literature searches were conducted in PubMed and CNKI,and the time limit for searching was from the time of database construction to September 2024.Literature obtained from the screening search was analyzed,summarized and concluded,and finally 79 relevant papers were summarized.RESULTS AND CONCLUSION:(1)The occurrence and development of peri-implantitis is closely related to its complex microbial characteristics,which stimulates the body to produce an immune-inflammatory response and exacerbates peri-implant bone resorption,and the signaling pathway plays an important role in regulating the process.Due to the limitations of the current development of technologies such as microbial cultivation and proteomics,the understanding of microbial characteristics,immune response mechanisms,and signaling pathways in peri-implantitis is still not comprehensive enough.Therefore,a lot of clinical and basic research is still needed for peri-implantitis.(2)According to the characteristics of the immuno-inflammatory microenvironment of peri-implantitis,reducing the release of pro-inflammatory factors,modulating the relevant signaling pathways,inhibiting alveolar bone resorption,and promoting new bone generation is expected to be an effective strategy for the prevention and treatment of peri-implantitis.
作者
陈豪杰
王黛
沈山
Chen Haojie;Wang Dai;Shen Shan(School of Stomatology,Jinan University,Guangzhou 510632,Guangdong Province,China)
出处
《中国组织工程研究》
北大核心
2026年第8期2054-2062,共9页
Chinese Journal of Tissue Engineering Research
基金
广州市科技计划市校院联合资助项目(202201020031),项目负责人:沈山
广东省医学科学技术研究项目。
关键词
种植体周围炎
骨结合
龈下菌群
免疫炎症微环境
信号通路
工程化口腔材料
peri-implantitis
osseointegration
subgingival flora
immune-inflammatory microenvironment
signaling pathway
engineered dental material
