摘要
背景:氧化应激与多种口腔疾病的发病有关,抗氧化纳米材料具有增强的活性氧清除特性,可以改善氧化应激,在口腔疾病中具有广阔的应用前景。目的:总结近年来抗氧化纳米材料的研究进展以及在口腔疾病中的应用、不足和未来研究方向。方法:以“reactive oxygen,antioxidant,nano,oxidative stress,oral”为关键词在PubMed和Web of Science数据库中检索文献,以“活性氧,抗氧化,纳米,氧化应激,口腔”为关键词在中国知网中检索文献,排除与研究主题关联性不强的文章,最终纳入103篇文献进行综述。结果与结论:氧化应激是口腔多种疾病发病的机制之一,清除过量产生的活性氧并纠正氧化与抗氧化失调,是治疗口腔相关疾病的重要措施。抗氧化纳米材料因纳米结构特性具有高效的活性氧清除能力,能够改善机体氧化应激,促进相关疾病的恢复,在口腔相关疾病的研究应用中具有显著效果。抗氧化纳米材料合成原料昂贵、工艺复杂且在体内应用的长期安全性不明确,还需要进一步研究改进和验证。未来抗氧化纳米材料在口腔疾病中的研究应用需多学科交叉,同时结合大数据和人工智能等领域,在材料的设计、实验、应用和验证等方面进行优化,以实现安全、有效且舒适的个性化口腔疾病治疗。
BACKGROUND:Oxidative stress is linked to the development of numerous oral disorders.Antioxidant nanomaterials possess enhanced reactive oxygen species scavenging properties and can reduce oxidative stress,presenting significant potential for application in oral health.OBJECTIVE:To summarize the research progress of antioxidant nanomaterials in recent years,as well as their applications,deficiencies,and future research directions in oral diseases.METHODS:Literature was retrieved in PubMed and Web of Science databases using the keywords“reactive oxygen,antioxidant,nano,oxidative stress,oral,”and literature was retrieved in CNKI using the same keywords.Articles with weak relevance to the research topic were excluded,resulting in a final inclusion of 103 publications for analysis.RESULTS AND CONCLUSION:Oxidative stress is one of the mechanisms underlying the pathogenesis of various oral diseases.Eliminating excess reactive oxygen species and rebalancing oxidation and antioxidation is a crucial approach to treating oral-related diseases.Antioxidant nanomaterials have efficient reactive oxygen species scavenging ability due to their nanostructure characteristics,can improve the body's oxidative stress,promote the recovery of related diseases,and have significant effects in the research and application of oral-related diseases.The raw materials for the synthesis of antioxidant nanomaterials are expensive,the process is complex,and the long-term safety of in vivo application is unclear,which requires further research,improvement and verification.In the future,the research and application of antioxidant nanomaterials in oral diseases require multidisciplinary cross-disciplinary research,while combining fields such as big data and artificial intelligence to optimize the design,experiment,application,and verification of materials to achieve safe,effective,and comfortable personalized oral disease treatment.
作者
杨学涛
朱梦菡
张宸熙
孙一民
叶玲
Yang Xuetao;Zhu Menghan;Zhang Chenxi;Sun Yimin;Ye Ling(Department of Endodontics,National Key Laboratory of Oral Disease Prevention and Control&National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,Sichuan Province,China)
出处
《中国组织工程研究》
北大核心
2026年第8期2044-2053,共10页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金项目(U21A20368),项目负责人:叶玲
中国博士后科学基金资助项目(BX20230240),项目负责人:孙一民
四川省科技计划项目(2024NSFSC1581),项目负责人:孙一民。
关键词
活性氧
氧化应激
氧化
抗氧化
抗氧化酶
纳米材料
个性化医疗
口腔疾病
工程化口腔材料
reactive oxygen
oxidative stress
oxidation
antioxidants
antioxidant enzyme
nanomaterial
personalized healthcare
oral disease
engineered oral material
