摘要
多囊卵巢综合征(Polycystic ovary syndrome,PCOS)是一种严重影响女性生殖和代谢健康的复杂疾病,糖代谢重编程指向能量代谢的根本性变化,贯穿PCOS能量代谢失衡、激素异常、胰岛素抵抗增加及慢性炎症状态等多个关键环节,是PCOS发病机制中的核心病理环节。“脾气散精”理论是对脾脏功能的高度概括,是保证脏器正常运行、气血津液输布的重要条件,是中医药治疗PCOS的重要理论支撑。本文基于“脾气散精”理论,以糖代谢重编程为切入点探讨调控PCOS的作用。助脾散精中药治疗PCOS的机制与调节糖代谢重编程密切相关,为中医药治疗PCOS提供了一种新的研究思路。
Polycystic ovary syndrome(PCOS)is a complex disease that significantly impacts women’s reproductive and metabolic health.The reprogramming of glucose metabolism points to fundamental changes in energy metabolism,which are central to the imbalance in energy metabolism,hormonal abnormalities,increasing insulin resistance,and chronic inflammatory states observed in PCOS.This represents a core pathological link in the pathogenesis of PCOS.The theory of“Spleen Qi to Dispersing Essence”provides a comprehensive overview of spleen function,essential for ensuring the normal operation of organs and the distribution of Qi,blood,and bodily fluids.It serves as a crucial theoretical support for the treatment of PCOS with traditional Chinese medicine.This article explores the role of regulating PCOS based on the theory of“Spleen Qi to Dispersing Essence”with a focus on the reprogramming of glucose metabolism.The mechanism of traditional Chinese medicinal treatments that assist Spleen Qi to Dispersing Essence is closely related to regulating glucose metabolism reprogramming,offering a novel research direction for the treatment of PCOS with TCM.
作者
商婷婷
陈雯玥
吴蝶
顾晨曦
邹姝
任青玲
SHANG Tingting;CHEN Wenyue;WU Die;GU Chenxi;ZOU Shu;REN Qingling(The Affiliated Hospital of Nanjing University of Chinese Medicine,The Chinese Clinical Medicine Innovation Center of Obstetrics,Gynecology and Reproduction in Jiangsu Province,Nanjing 210029,China)
出处
《世界科学技术-中医药现代化》
北大核心
2025年第3期878-886,共9页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会青年科学基金项目(82104904):基于LPS/NLRP3通路研究燮和饮调节肠道Akk菌改善PCOS-IR的作用机制,负责人:陈雯玥
江苏省中医药管理局中医临床医学创新中心研究项目(ZX202102):江苏省中医妇产生殖临床医学创新中心,负责人:任青玲。
关键词
PCOS
脾气散精
糖代谢重编程
胰岛素抵抗
Polycystic ovary syndrome(PCOS)
Spleen qi to dispersing essence
Glucose metabolic reprogramming
Insulin resistance
