摘要
目的分析儿童支原体肺炎治疗中喜炎平注射液与阿奇霉素联合用药方案的临床效果及对炎症指标的影响。方法方便选取2023年8月—2024年8月贵州省贞丰县人民医院收治的80例支原体肺炎患儿为研究对象,根据不同治疗方法分为两组,各40例,对照组应用阿奇霉素治疗,观察组联合喜炎平注射液治疗。对比两组炎症指标、症状缓解和不良体征消失时间、治疗效果、不良反应发生情况。结果治疗后,观察组超敏C反应蛋白(4.31±0.96)g/L、肿瘤坏死因子α(10.13±2.03)ng/L、白细胞介素6(17.56±3.39)ng/L、白细胞介素33(11.17±2.10)ng/L,低于对照组(8.27±1.15)g/L、(20.31±3.26)ng/L、(23.32±4.15)ng/L、(21.26±4.20)ng/L,差异均有统计学意义(t=16.719,16.765,6.798,13.590;P均<0.05)。观察组憋喘缓解时间(3.67±0.64)d、咳嗽缓解时间(6.50±1.07)d、肺部啰音消失时间(5.63±1.15)d、高热消失时间(4.41±0.96)d,短于对照组的(4.73±1.02)d、(8.10±1.15)d、(7.63±1.52)d、(5.69±1.12)d,差异均有统计学意义(t=5.567,6.442,6.636,5.488;P均<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿奇霉素联合喜炎平注射液治疗儿童支原体肺炎,可显著增强抗炎效果,加快临床症状改善,且未增加不良反应发生率。
Objective To analyze the clinical effect of Xiyanping injection combined with azithromycin in the treatment of mycoplasma pneumonia in children and its influence on inflammatory indexes.Methods A total of eighty children with mycoplasma pneumonia admitted to Guizhou Zhenfeng County People's Hospital from August 2023 to August 2024 were conveniently selected as the research objects.According to different treatment methods,they were divided into two groups,forty cases in each group.The control group was treated with azithromycin,and the observation group was treated with Xiyanping injection.The inflammatory indexes,symptom relief and disappearance time of adverse signs,treatment effect and occurrence of adverse reactions were compared between the two groups.Results After treatment,the levels of high-sensitivity C-reactive protein(4.31±0.96)g/L,tumor necrosis factor(10.13±2.03)ng/L,interleukin 6(17.56±3.39)ng/L and interleukin 33(11.17±2.10)ng/L in the observation group were lower than those in the control group(8.27±1.15)g/L,(20.31±3.26)ng/L,(23.32±4.15)ng/L and(21.26±4.20)ng/L,the differences were statistically significant(t=16.719,16.765,6.798,13.590;all P<0.05).The wheezing remission time(3.67±0.64)d,cough remission time(6.50±1.07)d,lung rale disappearance time(5.63±1.15)d,and high heat disappearance time(4.41±0.96)d in the observation group were shorter than(4.73±1.02)d,(8.10±1.15)d,(7.63±1.52)d,(5.69±1.12)d in the control group,the differences were statistically significant(t=5.567,6.442,6.636,5.488;all P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Azithromycin combined with Xiyanping injection in the treatment of mycoplasma pneumonia in children can significantly enhance the anti-inflammatory effect,accelerate the improvement of clinical symptoms,and do not increase the incidence of adverse reactions.
作者
胡全
汪武汉
王立斌
HU Quan;WANG Wuhan;WANG Libin(Department of Pediatrics,Guizhou Zhenfeng County People's Hospital,Zhenfeng 562200,Guizhou,China)
出处
《系统医学》
2025年第10期161-164,共4页
Systems Medicine
关键词
小儿支原体肺炎
喜炎平注射液
阿奇霉素
炎症反应
Mycoplasma pneumonia in children
Xiyanping injection
Azithromycin
Inflammatory response
