摘要
目的探讨兰索拉唑联合马来酸曲美布汀在老年反流性食管炎(reflux esophagitis,RE)患者中的应用效果。方法选择2023年1月至2023年10月信阳市申城医院收治的90例老年RE患者,根据随机数字表法进行分组。对照组45例单纯予以PPI治疗,餐前30 min口服兰索拉唑,每日1次,每次30 mg;观察组45例在对照组基础上加用促动力药物治疗,餐前口服马来酸曲美布汀,每日3次,每次100 mg。两组均用药8周。观察两组临床有效率、症状改善、上消化道动力改善与不良反应发生情况。结果两组比较,观察组总有效率更高(P<0.05);观察组患者各项临床症状消失时间均较对照组短(P<0.05);与本组治疗前相比,两组治疗后的食管上括约肌静息压、下食管括约肌静息压及血清促胃动素水平均出现升高,且观察组升高幅度比对照组大(P<0.05);两组在不良反应发生率比较方面差异无统计学意义(P>0.05)。结论促动力药物与PPI联合治疗老年RE患者的疗效优于单用PPI治疗,患者症状改善快,有利于改善患者上消化道动力,且不增加不良反应的发生率。
Objective To investigate the effect of lansoprazole combined with trimebutin maleate in elderly patients with reflux esophagitis.Methods 90 elderly RE patients admitted to Shencheng Hospital of Xinyang City from January 2023 to October 2023 were enrolled and divided into 2 groups by randomly.The control group consisted of 45 patients who were treated with PPI alone,taking lansoprazole orally 30 minutes before meals,once a day,30 mg each time.The observation group consisted of 45 patients who were treated with additional prokinetic drugs on top of the control group,taking trimebutine maleate orally three times a day,100 mg each time before meals,for 8 weeks.Clinical effective rate,symptom improvement,upper gastrointestinal motility improvement and adverse reactions were observed in 2 groups.Results The observation group demonstrated a significantly higher overall response rate compared to the control group(P<0.05);the time to resolution of all clinical symptoms in the observation group was significantly shorter than that in the control group(P<0.05).Compared to baseline(pre-treatment)values within each group,both groups exhibited significant increases in upper esophageal sphincter resting pressure,lower esophageal sphincter resting pressure,and serum motilin levels after treatment.The magnitude of these increases was greater in the observation group than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between 2 groups(P>0.05).Conclusion The combination therapy of prokinetic drugs and PPI is more effective in treating elderly patients with RE than using PPI alone.The patient′s symptoms improve faster,which is more conducive to improving upper gastrointestinal motility and does not increase the incidence of adverse reactions.
作者
黄远伟
李士坤
梁海建
HUANG Yuanwei;LI Shikun;LIANG Haijian(Shencheng Hospital,Xinyang City,Xinyang,China,464000;Xinyang Central Hospital,Xinyang,China,464000;Xinyang People′s Hospital,Xinyang,China,464000)
出处
《食管疾病》
2025年第2期115-118,共4页
Journal of Esophageal Diseases
