摘要
目的:评价中孕期规范化产前超声检查对胎儿先天性心脏病(CHD)筛查效果。方法:收集2023年6月-2024年6月本院接受产前检查的中孕期孕妇3996例临床资料,均进行规范化产前超声检查并随访,分析产前超声检查结果与新生儿超声检查及引产儿病理解剖结果符合情况,计算产前超声检查胎儿CHD检出率、漏诊率、误诊率以及检出胎儿CHD的灵敏度、特异度及准确性。结果:经新生儿超声检查结果及引产儿病理解剖结果证实,3996例中孕期孕妇中有30例胎儿患有CHD(0.7%),产前超声检查诊断28例,产前超声胎儿CHD检出率为93.3%,漏诊率为6.7%;产前超声检出的28例CHD胎儿中,20例正常分娩后经新生儿超声检查确诊,8例引产后经病理解剖确诊,误诊率为0%,灵敏度93.3%、特异度100%及准确性99.95%。高危孕妇中CHD胎儿发生率(2.1%,6/286)高于非高危孕妇(0.7%,24/3710)(P<0.05)。结论:中孕期规范化产前超声检查对胎儿CHD的检出率及诊断率较高,高危孕妇CHD胎儿发生率较高,临床应加强对高危人群产前超声检查。
Objective:To evaluate the effectiveness of the standardized prenatal ultrasound of pregnant women for screening their fetal congenital heart disease(CHD)during the second trimester of pregnancy.Methods:The clinical data of 3996 pregnant women who underwent the standardized prenatal ultrasound examination and were followed up in the hospital during the second trimester of pregnancy from June 2023 to June 2024 were collected in this study.The coincidence situation between the prenatal ultrasound examination and neonatal ultrasound examination results of the women and their fetal pathological autopsy results after induced labor was analyzed.The detection rate,the missed diagnosis rate,the misdiagnosis rate,the sensitivity,the specificity and the accuracy of the fetal CHD screened by the prenatal ultrasound examination were calculated,Results:According to the results of the neonatal ultrasound examination or the pathological anatomy of the induced fetus,there were 30 women with the fetal CHD in 3996 pregnant women,with the rate of 0.7%.There were 28 women with the fetal CHD diagnosed by prenatal ultrasound in 30 pregnant women with fetal CHD,the detection rate of the fetal CHD was 93.3%and the missed diagnosis rate was 6.7%.Among the 28 fetuses with the fetal CHD detected by prenatal ultrasound,20 newborns were diagnosed by the neonatal ultrasound after delivery and 8 cases were diagnosed by the pathological anatomy after induced labor,and the misdiagnosis rate,the sensitivity,the specificity and the accuracy of which were 0%,93.3%,100%and 99.95%,respectively.The incidence of the fetal CHD of the pregnant women with high-risk factors was 2.1%(6/286),and which was significantly higher than that(0.7%,24/3710)of the pregnant women without high-risk factors(P<0.05).Conclusion:The standardized prenatal ultrasound examination for the pregnant women during the second trimester of pregnancy has the higher detection rate and diagnostic rate for their fetal CHD.The incidence of the fetal CHD of the pregnant women with high-risk factors is higher,so the prenatal ultrasound examination for the pregnant women with high-risk factors should be strengthened attention in clinic.
作者
王金花
宋宁
郑佳能
董敏
王书涵
WANG Jinhua;ZHENG Jianeng;DONG Min;SONG Ning;WANG Shuhan(Yuhang District Health Bureau,Hangzhou,Zhejiang Province,311121;Hangzhou Yihehuisheng Technology limited Company,Hangzhou;The Second People's Hospitalof Yuhang District,Hangzhou;Zhejiang Chinese Medical University,Hangzhou)
出处
《中国计划生育学杂志》
2025年第6期1441-1444,共4页
Chinese Journal of Family Planning
基金
浙江省重点研发计划(2021C03030)。
关键词
中期妊娠
规范化产前超声检查
胎儿
先天性心脏病
筛查效果
The second trimester of pregnancy
Standardized prenatal ultrasound examination
Fetus
Congenital heart disease
Screening effect
