摘要
非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是最普遍的慢性肝病,已成为世界公共卫生问题,其患病率也显示出逐渐上升的态势。无论是单纯性脂肪肝、非酒精性脂肪性肝炎(nonalcoholic steatohepatitis,NASH),都有可能进一步演变为肝硬化、肝衰竭和肝癌等一系列肝脏相关疾病。通过对影响NAFLD产生的众多因素进行研究,发现其主要病理机制为脂肪的过多合成,且难以被转运入血,从而引起了大量脂质蓄积。酒精对肝脏有直接损伤作用,会抑制肝脏脂肪的分解,最终形成酒精性脂肪肝(alcoholic fatty liver disease,AFLD)。然而酒精对NAFLD发病是否具有协同作用仍存在争议,因此该文针对酒精摄入对NAFLD的影响及其潜在的作用机制进行综述。
NAFLD is the most prevalent chronic liver disease,which has become a world public health issue and the incidence rate is also showing an increasing trend.A series of liver diseases,such as simple fatty liver disease,NASH,liver cirrhosis,liver failure and liver cancer,can be collectively referred to as NAFLD.Through the study of numerous factors that influence the production of NAFLD,it has been found that the main pathological mechanism is excessive synthesis of fat,which is difficult to be transported into the blood,causing massive lipid accumulation.Alcohol has a direct damaging effect on liver and will inhibit the breakdown of liver fat,eventually forming AFLD.However,it is still controversial whether alcohol has a synergistic effect on NAFLD onset.This article provides a review on the effect of alcohol intake on NAFLD and its potential mechanisms of action.
作者
朱昊清
吴艳玲
南极星
廉丽花
ZHU Hao-qing;WU Yan-ling;NAN Ji-xing;LIAN Li-hua(College of Pharmacy,Yanbian University,Yanji Jilin 133002,China)
出处
《中国药理学通报》
北大核心
2025年第7期1227-1230,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 82460803,82074095,82360850)。
关键词
非酒精性脂肪肝
酒精
酒精摄入对脂肪肝的两面性
肝损伤
发病机制
研究进展
nonalcoholic fatty liver disease
alcohol
dual effects of alcohol intake on fatty liver
liver damage
pathogenesis
research progress
