摘要
小檗碱(berberine,BBR)是一种从毛茛科黄连、芸香科黄柏、小檗科三颗针等多种药用植物的根和根茎中提取的异喹啉生物碱。近年来随着研究的深入,发现BBR在多种神经精神系统疾病模型中展现出了显著的防治效果。该文总结了BBR在神经精神系统疾病方面的作用机制研究进展,为进一步在临床上防治神经精神系统疾病提供更加深入的理论支撑。
Berberine is a kind of isoquinoline alkaloid extracted from the roots and rhizomes of many medicinal plants,such as Coptis chinensis of Ranunculus family,Phellodendron chinensis of rutaceae family,and Berberine Sanacanthus family.In recent years,with the deepening of research,berberine has shown remarkable prevention and treatment effect in a variety of neuropsychiatric disease models.This paper summarizes the research progress of berberine in neuropsychiatric diseases and provides theoretical support for further clinical prevention and treatment of neuropsychiatric diseases.
作者
李盼盼
兰瑞
胡文静
黎梦雅
焦水治
刘亚寒
王保奇
LI Pan-pan;LAN Rui;HU Wen-jing;LI Meng-ya;JIAO Shui-zhi;LIU Ya-han;WANG Bao-qi(Encephalopathy center,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine;the First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《中国药理学通报》
北大核心
2025年第7期1217-1222,共6页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81973618,81904264,81904265,81303011)
河南省中医药科学研究专项课题(No 2019ZY1006)。
