摘要
目的:观察阵列微针治疗肺癌术后慢性咳嗽的临床疗效。方法:选取2022年1月—2023年12月在上海中医药大学附属岳阳中西医结合医院接受治疗的62例肺癌术后慢性咳嗽患者,按照随机数字表法分为试验组和对照组各31例。对照组在常规中药抗肿瘤基础上使用假针进行安慰治疗,试验组在常规中药抗肿瘤基础上使用阵列微针治疗。2组均治疗4周。比较2组临床疗效,观察2组治疗前后中文版莱斯特咳嗽问卷(LCQ-MC)评分、咳嗽症状积分(CSS)、咳嗽视觉模拟评分法(VAS)评分以及炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、白细胞介素-13(IL-13)]水平的变化。结果:治疗后,总有效率试验组87.10%(27/31),高于对照组67.74%(21/31),差异有统计学意义(P<0.05)。2组生理区域、心理区域、社会区域评分及LCQ-MC总分均较治疗前升高(P<0.05),试验组生理区域、心理区域、社会区域评分及LCQ-MC总分均较对照组升高更明显(P<0.05)。2组CSS及咳嗽VAS评分均较治疗前降低(P<0.05),试验组CSS及咳嗽VAS评分均低于对照组(P<0.05)。TNF-α、IL-8、IL-13水平同组治疗前后比较及治疗后组间比较,差异均无统计学意义(P>0.05)。结论:阵列微针对肺癌术后慢性咳嗽治疗有效,其对咳嗽的改善作用可能不是通过缓解炎症反应实现。
Objective:To observe the clinical effect of array microneedling in treating chronic cough after lung cancer surgery.Methods:A total of 62 patients with chronic cough after lung cancer surgery who were treated at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to December 2023 were selected and divided into a trial group and a control group according to the random number table method,each with 31 cases.The control group received sham acupuncture as a placebo treatment on the basis of conventional Chinese herbal anti-tumor therapy,while the trial group received array microneedling treatment on the same basis.Both groups underwent treatment for four weeks.Clinical efficacy was compared between the two groups,and changes in the following parameters were observed before and after treatment:Leicester Cough Questionnaire-Mainland Chinese version(LCQ-MC)scores,Cough Symptom Score(CSS),Visual Analogue Scale(VAS)scores for cough,and levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),and interleukin-13(IL-13)].Results:After treatment,the total effective rate in the trial group was 87.10%(27/31),higher than that in the control group at 67.74%(21/31),with the difference being significant(P<0.05).Both groups showed significant increases in LCQ-MC scores in the physical,psychological,and social domains compared to those before treatment(P<0.05),with the trial group showing more pronounced improvements in these domains and the total LCQ-MC score compared to the control group(P<0.05).The CSS and VAS scores for cough were decreased significantly in both groups compared to those before treatment(P<0.05),with the trial group having lower scores than the control group(P<0.05).Levels of TNF-α,IL-8,and IL-13 did not show significant differences within or between groups before and after treatment(P>0.05).Conclusion:Array microneedling treatment is effective for chronic cough after lung cancer surgery.The improvement in cough symptoms may not be achieved through the alleviation of inflammatory reactions.
作者
王欢
龚亚斌
项瑞龙
姚重界
赵琛
WANG Huan;GONG Yabin;XIANG Ruilong;YAO Chongjie;ZHAO Chen(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;School of Acupuncture-Moxibustion and Tuina,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《新中医》
2025年第12期161-166,共6页
New Chinese Medicine
基金
上海中医药大学附属岳阳医院院级青年基金项目(2021yyjq03)。
关键词
肺癌术后
慢性咳嗽
阵列微针
炎症因子
After lung cancer surgery
Chronic cough
Array microneedling
Inflammatory factors
