摘要
目的:观察槐耳颗粒联合新辅助化疗治疗老年非小细胞肺癌(NSCLC)的临床疗效及对肿瘤标志物、T淋巴细胞亚群的影响。方法:选取2021年8月—2023年12月丽水市人民医院治疗的80例老年NSCLC患者为研究对象,按照随机数字表法分为对照组和研究组各40例。对照组采用新辅助化疗方法治疗,研究组在对照组基础上加用槐耳颗粒治疗。2组均以21天为1个疗程,共治疗2个疗程。治疗后评估2组临床疗效,比较2组血清肿瘤标志物[癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)]水平、认知功能及T淋巴细胞亚群水平。结果:治疗后,研究组客观有效率(ORR)、疾病控制率(DCR)分别为87.50%(35/40)、95.00%(38/40),对照组分别为60.00%(24/40)、80.00%(32/40),2组比较,差异均有统计学意义(P<0.05)。治疗后,2组CEA、CYFRA21-1水平均较治疗前降低(P<0.05),且研究组2项指标水平均低于对照组(P<0.05)。治疗后,研究组认知功能障碍发生率为7.50%(3/40),对照组为25.00%(10/40),2组比较,差异有统计学意义(P<0.05)。治疗后,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前降低(P<0.05),CD8^(+)水平均较治疗前升高(P<0.05);但研究组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组(P<0.05),CD8^(+)水平低于对照组(P<0.05)。治疗期间,2组皮疹、恶心呕吐、贫血、肝肾功能异常、腹泻等不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:槐耳颗粒联合新辅助化疗治疗老年NSCLC疗效显著,能够改善患者认知功能及免疫功能,降低肿瘤标志物水平,且安全性良好。
Objective:To observe the clinical effect of Huai'er Granules combined with neoadjuvant chemotherapy on non-small cell lung cancer(NSCLC)in senile and its effects on tumor markers and T lymphocyte subsets.Methods:A total of 80 cases of senile NSCLC patients treated at Lishui City People's Hospital from August 2021 to December 2023 were selected and divided into the control group and the study group according to the random number table method,with 40 cases in each group.The control group was treated with neoadjuvant chemotherapy,and the study group was additionally treated with Huai'er Granules in addition to the neoadjuvant chemotherapy.Both groups were treated for two cycles,with a treatment cycle lasting 21 days.After treatment,clinical effects were evaluated;the changes in serum tumor markers[carcinoembryonic antigen(CEA)and cytokeratin 19 fragment(CYFRA21-1)],cognitive function,and T lymphocyte subsets were compared between the two groups.Results:After treatment,the objective response rate(ORR)and disease control rate(DCR)in the study group were 87.50%(35/40)and 95.00%(38/40)respectively,compared to 60.00%(24/40)and 80.00%(32/40)in the control group,with significant differences between the two groups(P<0.05).After treatment,the levels of CEA and CYFRA21-1 in the two groups were reduced when compared with those before treatment(P<0.05),with the study group showing significantly lower levels than the control group(P<0.05).After treatment,the incidence of cognitive dysfunction was 7.50%(3/40)in the study group and 25.00%(10/40)in the control group,with a significant difference(P<0.05).After treatment,the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the two groups were decreased when compared with those before treatment(P<0.05),and CD8^(+)levels were increased(P<0.05);but the study group had significantly higher levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)and lower level of CD8^(+)compared to the control group(P<0.05).During the treatment,there was no significant difference in the incidence of adverse reactions such as rash,nausea and vomiting,anemia,liver and kidney dysfunction,and diarrhea between the two groups(P>0.05).Conclusion:Huai'er Granules combined with neoadjuvant chemotherapy have a significant curative effect on senile NSCLC patients,which can improve cognitive and immune functions and reduce tumor marker levels,with good safety.
作者
陈柳妃
陈柯润
陆明贝
CHEN Liufei;CHEN Kerun;LU Mingbei(Department of Thoraco-Cardiac Surgery,Lishui City People's Hospital,Lishui Zhejiang 323000,China;Intensive Care Unit,Lishui City People's Hospital,Lishui Zhejiang 323000,China;Department of Thyroid and Breast Surgery,Lishui City People's Hospital,Lishui Zhejiang 323000,China)
出处
《新中医》
2025年第12期156-160,共5页
New Chinese Medicine
基金
浙江省中医药科技计划项目(2023ZL315)。
关键词
非小细胞肺癌
槐耳颗粒
新辅助化疗
肿瘤标志物
T淋巴细胞亚群
Non-small cell lung cancer
Huai'er Granules
Neoadjuvant chemotherapy
Tumor markers
T lymphocyte subsets
