摘要
目的 探讨血清可溶性程序性死亡蛋白1(sPD-1)、脂蛋白a[Lp(a)]、骨形态发生蛋白-7(BMP-7)水平联合检测对原发性肾病综合征(PNS)患者疾病转归不良的预测价值。方法 选取义马煤业集团股份有限公司总医院2020年6月至2022年6月收治的179例PNS患者为研究对象,根据治疗6个月后疾病转归情况将患者分为转归不良组(31例)和转归良好组(148例)。比较两组一般临床资料,比较两组血清sPD-1、Lp(a)、BMP-7水平,通过logistic回归分析PNS患者转归不良的影响因素,通过ROC分析血清各指标联合检测对PNS患者转归不良的预测价值。结果 入院时转归不良组血清BUN、Scr、sPD-1、Lp(a)水平高于转归良好组,BMP-7水平低于转归良好组(P<0.05);入院时BUN、Scr、sPD-1、Lp(a)水平为PNS患者转归不良的危险因素,BMP-7水平为其保护因素,且各指标联合预测PNS患者转归不良的AUC为0.803。结论 血清Scr、sPD-1、Lp(a)水平与PNS患者病情转归密切相关,可为临床早期预测PNS患者疾病转归情况提供可靠参考。
Objective To investigate the predictive value of changes in the levels of serum soluble programmed death protein 1(sPD-1),lipoprotein a[Lp(a)],and bone morphogenetic protein-7(BMP-7)on disease regression in patients with primary nephrotic syndrome(PNS).Methods A total of 179 patients with PNS admitted to General Hospital of Yima Coal Industry Group Co.,Ltd.from June 2020 to June 2022 were selected as the study objects.According to the disease outcomes after 6 months of treatment,the patients were divided into poor outcome group(31 cases)and good outcome group(148 cases).General clinical data and serum levels of sPD-1,Lp(a)and BMP-7 were compared between the two groups.The influencing factors of adverse outcomes in PNS patients were analyzed by logistic regression,and the predictive value of combined detection of serum indicators for adverse outcomes in PNS patients was analyzed by ROC.Results The serum levels of BUN,Scr,sPD-1 and LP(a)in the poor prognosis group were higher than those in the good prognosis group at admission,and the levels of BMP-7 were lower than those in the good prognosis group(P<0.05).The levels of BUN,Scr,sPD-1 and LP(a)were risk factors for poor prognosis of PNS patients at admission,and the level of BMP-7 was its protective factor.The AUC of the combined prediction of these indicators for poor prognosis of PNS patients was 0.803.Conclusion Serum Scr,sPD-1,Lp(a)levels are closely related to the disease outcome of PNS patients,and can provide a reliable reference for early clinical prediction of disease outcome of PNS patients.
作者
吉双
JI Shuang(Department of Nephrology,General Hospital of Yima Coal Industry Group Co.,Ltd.,Sanmenxia 472300,China)
出处
《河南医学研究》
2025年第11期2056-2059,共4页
Henan Medical Research
