摘要
低氧诱导因子(HIF)作为机体适应低氧环境的核心分子,通过感知细胞内氧分压变化,一方面调控与低氧适应相关的基因表达,从而提升机体在细胞、组织和器官水平上的低氧耐力;另一方面通过促进红细胞生成、血管新生和调控机体能量代谢等途径,提高机体的低氧耐力。低氧耐力的提升对于预防和治疗低氧相关疾病、提高运动员竞技水平、保障高原作业人员工作效率及提升个人生活质量具有重要意义。该文就HIF与低氧耐力的关系及相关机制进行综述,旨在为机体低氧耐力的提升提供新的思路。
Hypoxia inducible factors(HIFs)are core molecules that enable the body to adapt to hypoxia environments.By sensing changes in intracellular oxygen pressure,HIFs regulate gene expression related to hypoxia adaptation,thereby enhancing the body's hypoxia tolerance at cellular,tissue and organ levels.On the other hand,HIFs promote the generation of red blood cells,angiogenesis,and regulate the body's energy metabolism,thereby improving its hypoxia tolerance.The enhancement of hypoxia tolerance is of great significance for the prevention and treatment of hypoxia-related diseases,upgrading of athletes'performance,enhancement of workers'efficiency at high-altitudes,and the improvement of individuals'quality of life.This article reviews the relationships between HIFs and hypoxia tolerance as well as related mechanisms in order to provide strategies for enhancing hypoxia tolerance in the body.
作者
仁青扎西
杨皓
王瑞
梁雅楠
柴锐青
张沛然
张同梅
赵星成
RENQING Zhaxi;YANG Hao;WANG Rui;LIANG Ya′nan;CHAI Ruiqing;ZHANG Peiran;ZHANG Tongmei;ZHAO Xingcheng(Department of Aerospace Medical Training,Air Force Medical University,Xi′an 710032,China;Department of Biochemistry and Molecular Biology,School of Basic Medicine,Air Force Medical University,Xi′an 710032,China;Center of Clinical Aerospace Medicine,Air Force Medical University,Xi′an 710032,China)
出处
《军事医学》
2025年第3期233-238,共6页
Military Medical Sciences
基金
国家自然科学基金项目(82304019)
空军军医大学军事医学与航空医学重大问题科技攻关项目(2022ZZXM013)。
关键词
低氧诱导因子
低氧耐力
低氧适应
高原
hypoxia inducible factors
hypoxia tolerance
hypoxia adaption
plateau
