摘要
目的探讨在老年消化性溃疡伴发上消化道出血患者中使用蛇毒血凝酶联合泮托拉唑治疗对凝血功能及超敏C反应蛋白(hs-CRP)、皮质醇(Cor)的影响。方法选取2018年11月至2022年11月北京市垂杨柳医院住院诊治的96例老年消化性溃疡伴发上消化道出血患者,按随机原则分为观察组(48例)与对照组(48例)。观察组使用泮托拉唑联合蛇毒血凝酶治疗,对照组治疗药物仅使用泮托拉唑。对两组患者的以下临床指标进行比较:止血时间、输血量、住院时间、凝血时间、血红蛋白(Hb)、超敏C反应蛋白(hs-CRP)、皮质醇(Cor)水平以及不良反应发生情况。结果在止血时间、平均输血量和住院时间上,观察者均低于对照组;两组患者血红蛋白治疗后均升高,但升高幅度对照组偏低;两组hs-CRP、Cor均降低,观察者降低程度较高(P<0.05)。治疗后两组患者之间的药物不良反应发生率对比,差异无统计学意义(P>0.05)。结论蛇毒血凝酶联合泮托拉唑治疗老年消化性溃疡伴发上消化道出血的疗效显著,且止血迅速,不良反应少。
Objective To explore the effect of snake venom hemocoagulase combined with pantoprazole on coagulation function,highsensitivity C-reactive protein(hs-CRP)and cortisol(Cor)in elderly patients with peptic ulcer complicated with upper gastrointestinal hemorrhage.Methods A total of 96 elderly patients with peptic ulcer complicated with upper gastrointestinal hemorrhage who were hospitalized at Chuiyaliu Hospital in Beijing from November 2018 to November 2022 were randomly divided into the observation group(48 cases)and the control group(48 cases).The control group was only treated with pantoprazole,while the observation group was treated with pantoprazole combined with snake venom hemocoagulase.The following clinical indicators were compared between the two groups:hemostasis time,transfusion volume,hospitalization time,coagulation time,hemoglobin(Hb)levels,high-sensitivity C-reactive protein(hs-CRP)levels,cortisol(Cor)levels,and the occurrence of adverse reactions.Results The observation group had lower hemostasis time,average blood transfusion volume,and hospitalization time compared to the control group(P<0.05).After treatment,both groups of patients showed a increase in hemoglobin levels,Yet the extent of the escalation was more substantial in the observation group relative to the control group(P<0.05).Both groups of hs-CRP and Cor were reduced,and the observation group exhibited a greater reduction(P<0.05).In the aftermath of therapeutic intervention,the frequency of adverse drug reactions manifested in a manner devoid of statistically significant disparity when juxtaposing the two distinct patient assemblages(P>0.05).Conclusions Pantoprazole combined with snake venom hemocoagulase had good clinical effects on peptic ulcer accompanied with upper gastrointestinal hemorrhage in the elderly.It has fast hemostasis and fewer adverse reactions.
作者
魏晟
蒋大健
臧杰
谢俏
董丽凤
WEI Sheng;JIANG Dajian;ZANG Jie;XIE Qiao;DONG Lifeng(Department of Gastroenterology,Beijing Chuiyangliu Hospital,Beijing 100022,China)
出处
《中国医药指南》
2025年第17期58-60,共3页
Guide of China Medicine
关键词
溃疡伴出血
泮托拉唑
血凝酶
老年
Ulcer with bleeding
Pantoprazole
Hemocoagulase
Elderly
