摘要
目的:比较奥美拉唑、埃索美拉唑与泮托拉唑治疗上消化道出血的成本-效果。方法:随机抽取我院2008年上消化道出血病例112份分为3组,A组62例,静脉注射用奥美拉唑;B组22例,静脉注射用埃索美拉唑;C组28例,静脉注射用泮托拉唑。观察各组疗效,并运用经济学方法进行分析。结果:3组治疗有效率93.55%、95.45%、92.86%;不良反应发生率分别为19.35%、9.09%、14.29%;成本-效果比(C/E)分别为21.25、20.53、10.27。奥美拉唑和埃索美拉唑的增量成本-效果比(ΔCΔ/E)分别为1 499.42、388.65。结论:泮托拉唑是上消化道出血的较佳治疗药物。
OBJECTIVE： To evaluate the cost-effectiveness of Omeprazole,Esomeprazol and Pantoprazole for upper gastrointestinal bleeding.METHODS： In 2008,a total of 112 patients with upper gastrointestinal bleeding were randomly selected from our hospital and allocated to receive omeprazole（Group A,n=62）,esomeprazole（Group B,n=22） or pantoprazole（Group C,n=28）.The therapeutic efficacy was evaluated and pharmacoeconomic analysis was carried out.RESULTS： The effective rates of the three regimens were 93.55%,95.45% and 92.86%,respectively;the incidences of adverse drug reactions were 19.35%,9.09% and 14.29%,respectively;the costeffectiveness ratios were 21.25,20.53 and 10.27,respectively.Compared with therapeutic regimen C,the incremental cost-effectiveness ratios（ΔC /ΔE） for Omeprazole and Esomeprazole were 1 499.42 and 388.65,respectively.CONCLUSION： Pantoprazole was proved to be optimal for upper gastrointestinal bleeding.
出处
《中国医院用药评价与分析》
2010年第1期42-44,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
上消化道出血
成本-效果分析
奥美拉唑
埃索美拉唑
泮托拉唑
Upper gastrointestinal bleeding
Cost-effectiveness analysis
Omeprazole
Esomeprazole
Pantoprazole
