摘要
目的:探究输血前患者不规则抗体检测结果的临床意义及其对输血安全性和患者预后的影响。方法:选取2022年10月—2024年9月在样本医院输血的102例患者作为研究对象,将其中78例实施输血前不规则抗体检测的患者纳入观察组,将24例未实施不规则抗体检测的患者纳入对照组。比较两组患者输血总反应率,观察输血前检出不规则抗体患者的预后情况。结果:输血前不规则抗体检测共检测出不规则抗体15例,占比19.23%。78例输血前实施不规则抗体检测患者输血史比较,差异有统计学意义(t=7.429,P<0.05)。输血前不规则抗体筛查阳性分型抗-E占比最高,抗-Lea次之。15例不规则抗体阳性患者的Rh五项分型中CCDee占比最高,为26.67%,CcDEe、CcDee、ccDEE、ccDEe次之,占比均为13.33%。观察组患者输血反应总发生率低于对照组,差异有统计学意义(χ^(2)=3.966,P<0.05)。检出不规则抗体的15例患者经调整输血方案治疗后预后良好,未出现预后不良的情况。结论:输血前不规则抗体检测对于保证输血患者的输血安全性具有重要临床应用价值,根据不规则抗体检测的筛查结果为患者选择合适的血液输血,能够显著降低输血反应的发生风险,保证患者的输血安全性,改善患者预后。
Objective:To explore the clinical significance of irregular antibody detection before transfusion and its influence on transfusion safety and patient prognosis.Methods:A total of 102 patients who received blood transfusion in the hospital from October 2022 to September 2024 were selected as the study objects.Among them,78 transfusion patients with irregular antibody detection before transfusion were included in the observation group,and 24 transfusion patients without irregular antibody detection were included in the control group.The total transfusion response rate of the two groups was compared,and the prognosis of the patients with irregular antibodies detected before transfusion was observed.Results:Before blood transfusion,15 irregular antibody patients were detected,accounting for 19.23%.The blood transfusion history of 78 patients with irregular antibody detection before transfusion was compared,and the difference was statistically significant(t=7.429,P<0.05).The proportion of anti-E was the highest,followed by anti-LEA.Among the five Rh types of the 15 irregular antibody positive patients,CCDEe accounted for the highest proportion(26.67%),followed by CcDEe,CcDee,ccDEE and ccDEe,accounting for 13.33%.The total incidence of transfusion reaction in the observation group was lower than that in the control group,and the difference was statistically significant(χ^(2)=3.966,P<0.05).The 15 patients with irregular antibody detected had good prognosis after adjusting the transfusion regimen,but no bad prognosis.Conclusion:The detection of irregular antibody in patients before transfusion has important clinical application value to ensure the transfusion safety of transfusion patients.The selection of appropriate blood transfusion for patients according to the screening results of irregular antibody detection can significantly reduce the risk of transfusion reaction,ensure the transfusion safety of patients,and improve the prognosis of patients.
作者
李源
贾雷鸣
谢满晴
Li Yuan;Jia Leiming;Xie Manqing(Laboratory,Shangqiu Central Blood Station,Shangqiu,Henan,476000,China)
出处
《黑龙江医学》
2025年第11期1334-1336,共3页
Heilongjiang Medical Journal
关键词
输血
不规则抗体
检测
安全
预后
Blood transfusion
Irregular antibody
Detection
Safety
Prognosis
