摘要
目的 分析对维持性血液透析合并慢性心力衰竭应用酒石酸美托洛尔联合沙库巴曲缬沙坦的临床效果。方法 方便选取黔南州人民医院于2021年1月—2024年1月收治的120例维持性血液透析并慢性心力衰竭患者为研究对象。按治疗方法分为两组,每组60例。对照组采用沙库巴曲缬沙坦,观察组联合酒石酸美托洛尔治疗。对比两组血压、心功能分级情况、心功能指标及血清指标。结果 观察组收缩压(148.35±10.61)mmHg、舒张压(73.46±6.42)mmHg,低于对照组的(153.67±9.76)mmHg、(80.36±6.57)mmHg,差异均有统计学意义(t=2.077,2.901;P均<0.05)。观察组Ⅱ级的患者数量多于对照组,Ⅲ~Ⅳ级的患者数量少于对照组,观察组心功能指标及血清指标优于对照组,差异均有统计学意义(P均<0.05)。结论 酒石酸美托洛尔联合沙库巴曲缬沙坦能有效改善透析合并心力衰竭患者的心功能及血压。
Objective To analyze the clinical effect of applying metoprolol tartrate combined with sacubitril valsartan in patients with maintenance hemodialysis complicated with chronic heart failure.Methods A total of 120 patients with maintenance hemodialysis and chronic heart failure admitted to Qiannan People's Hospital from January 2021 to January 2024 were conveniently selected as the research subjects.They were divided into two groups according to the treatment methods,with 60 patients in each group.The control group was treated with sacubitril valsartan,and the observation group was treated with the combination of metoprolol tartrate.The blood pressure,cardiac function classification,cardiac function indexes and serum indexes were compared between the two groups.Results The systolic blood pressure(148.35±10.61)mmHg and diastolic blood pressure(73.46±6.42)mmHg in the observation group were lower than(153.67±9.76)mmHg and(80.36±6.57)mmHg in the control group,and the differences were statistically significant(t=2.077,2.901;both P<0.05).The number of patients with gradeⅡin the observation group was more than that in the control group,and the number of patients with gradeⅢ-Ⅳwas less than that in the control group,and the cardiac function indexes and serum indexes in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Metoprolol tartrate combined with sacubitril valsartan can effectively improve the blood pressure and cardiac function of patients with dialysis and heart failure.
作者
史源源
胡忠忠
邓觅
SHI Yuanyuan;HU Zhongzhong;DENG Mi(Department of Nephrology,Rheumatology and Immunology,Qiannan People's Hospital,Qiannan Prefecture 558000,Guizhou,China)
出处
《系统医学》
2025年第9期89-92,共4页
Systems Medicine
