摘要
目的:分析吡仑帕奈(PER)联合左乙拉西坦(LEV)治疗癫痫患儿的效果。方法:选取义马市煤业集团股份有限公司总医院2021年3月至2023年12月收治的97例癫痫患儿临床资料行回顾性研究,依照治疗方案差异分为两组,对照组(n=48)接受LEV治疗,观察组(n=49)接受PER联合LEV治疗。比较两组疗效、治疗前后临床症状[发作频率、持续时间、国立医院癫痫发作严重程度量表(NHS3)评分]、血清学指标[髓鞘碱性蛋白(MBP)、去甲肾上腺素(NE)、胶质纤维酸性蛋白(GFAP)、多巴胺(DA)、5-羟色胺(5-HT)、神经元特异性烯醇化酶(NSE)、S-100β蛋白(S-100β)]、脑电活动(θ波、β波、δ波、α波)、不良反应。结果:观察组总有效率91.84%较对照组72.92%高(P<0.05);治疗后,观察组发作频率、NHS3评分较对照组低,持续时间较对照组短(P<0.05);治疗后,两组血清NE、DA、5-HT、θ波、δ波水平均较治疗前高,血清NSE、MBP、GFAP、S-100β、β波、α波水平均较治疗前低,且观察组改善更为显著(P<0.05);观察组、对照组不良反应发生率分别为14.29%、10.42%,组间无明显差异(P>0.05)。结论:PER联合LEV治疗癫痫患儿效果显著,能有效改善临床症状,调节血清因子水平,且不会明显增加安全风险。
Objective:To analyze the efficacy of perampanel(PER)combined with levetiracetam(LEV)in the treatment of children with epilepsy.Methods:A retrospective study was conducted on the clinical data of 97 children with epilepsy admitted to General Hospital of Yima Coal Industry Group Co.,Ltd.from March 2021 to December 2023.The patients were divided into two groups according to the treatment regimen:the control group(n=48)received LEV treatment,and the observation group(n=49)received PER combined with LEV treatment.The efficacy,clinical symptoms before and after treatment[seizure frequency,duration,National Hospital Seizure Severity Scale(NHS3)score],serological indices[myelin basic protein(MBP),norepinephrine(NE),glial fibrillary acidic protein(GFAP),dopamine(DA),serotonin(5-HT),neuron-specific enolase(NSE),S-100βprotein(S-100β)],brain electrical activity(θwave,βwave,δwave,αwave),and adverse reactions were compared between the two groups.Results:The total effective rate in the observation group 91.84%was higher than that in the control group 72.92%(P<0.05).After treatment,the seizure frequency and NHS3 score in the observation group were lower than those in the control group,and the duration was shorter than that in the control group(P<0.05).After treatment,the levels of serum NE,DA,5-HT,θwave andδwave in both groups were higher than those before treatment,while the levels of serum NSE,MBP,GFAP,S-100β,βwave andαwave were lower than those before treatment,and the improvement in the observation group was more significant(P<0.05).The incidence of adverse reactions in the observation group and the control group was 14.29%and 10.42%,respectively,with no significant difference between the groups(P>0.05).Conclusion:The combined application of PER and LEV is significantly effective in the treatment of children with epilepsy,it can effectively improve clinical symptoms,regulate serum factor levels,and does not significantly increase safety risks.
作者
李珍珍
王伟伟
韩碧波
LI Zhenzhen;WANG Weiwei;HAN Bibo(Department of Pediatrics,General Hospital of Yima Coal Industry Group Co.,Ltd.,Sanmenxia 472000,China;Department of Pediatrics,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)
出处
《黑龙江医药科学》
2025年第6期20-22,27,共4页
Heilongjiang Medicine and Pharmacy
基金
河南省医学科技攻关联合共建项目,编号:LHGJ20207643。
关键词
吡仑帕奈
左乙拉西坦
癫痫患儿
神经损伤
perampanel
levetiracetam
children with epilepsy
nerve injury
