摘要
目的目的分析对视神经脊髓炎患者采取利妥昔单抗治疗的临床疗效。方法方法将院内神经内科近年来(2022年5月-2023年9月)收治的视神经脊髓炎患者50例作为本次观察对象,以随机数表法分组,即观察组(利妥昔单抗+常规治疗,25例)与对照组(常规治疗,25例),比较两组治疗后临床疗效、不良反应发生率(嗜睡、心慌、呼吸困难),分析两组治疗前后EDSS评分、视力水平(最差眼logMAR矫正视力、最佳眼平均logMAR矫正视力、平均logMAR矫正视力)。结果结果观察组与对照组治疗后临床疗效比较,可见前者高于后者,差异有统计学意义(P<0.05);两组治疗前EDSS评分、视力水平比较,差异无统计学意义(P>0.05),治疗后观察组与对照组EDSS评分、视力水平各项指标水平比较,前者改善效果优于后者,差异有统计学意义(P<0.05);对用药中出现嗜睡、心慌、呼吸困难等不良反应的统计发现,观察组不良反应发生率为4.0%,低于对照组的20.0%,差异有统计学意义(P<0.05)。结论结论在视神经脊髓炎患者治疗中采取利妥昔单抗治疗可提高治疗效果,改善视力状态,较常规治疗更能提高各项机体功能,且不增加不良反应,对提高治疗效果有重要作用,可在临床中推广。
Objective To analyze the clinical efficacy of rituximab treatment in patients with neuromyelitis optica.Methods 50 patients with optic neuromyelitis admitted in recent years(from May 2022 to September 2023)were the object of this observation by random number table,namely the observation group(rituximab+conventional therapy,25 cases)and the control group(conventional treatment,25 cases),compared the clinical efficacy after treatment and the incidence of adverse reactions(drowsiness,palpitation,dyspnea),and analyzed EDSS score,visual acuity level(worst eye logMAR corrected visual acuity,best eye logMAR corrected visual acuity,mean logMAR corrected visual acuity).Results The clinical efficacy of the observation group was higher than that of the control group after treatment,and the difference was statistically significant(P<0.05);there was no statistically significant difference in EDSS scores and visual acuity levels between the two groups before treatment(P>0.05).After treatment,the observation group showed better improvement in EDSS scores and visual acuity levels than the control group,and the difference was statistically significant(P<0.05).The statistical analysis of adverse reactions such as drowsiness,palpitations,and difficulty breathing during medication showed that the incidence rate in the observation group was 4.0%lower than that in the control group(20.0%),and the difference was statistically significant(P<0.05).Conclusion Taking rituximab treatment in the treatment of patients with neuromyelitis optica can improve the treatment effect,improve the visual acuity,improve the body function better than the conventional treatment,and do not increase the adverse reactions,which plays an important role in improving the treatment effect,and can be promoted in clinical practice.
作者
丁小洁
罗坤能
Ding Xiaojie;Luo Kunneng(Bijie Hospital,Zhejiang Provincial People’s Hospital,Bijie,Guizhou 551700,China)
出处
《首都食品与医药》
2025年第12期61-63,共3页
Capital Food Medicine
