摘要
卵巢早衰是指女性在40岁之前出现的月经异常、雌激素水平紊乱、生育能力下降为主要临床表现的一种严重的生殖系统疾病。自噬是哺乳动物细胞代谢的关键机制,在卵巢早衰的发病中起着关键作用。“正邪”理论作为描述疾病发生和发展的重要理论,与卵巢早衰疾病的发展密切相关。在这一点上,“正邪”理论强调正气与邪气的动态平衡,与细胞自噬在维持机体健康中的功能相契合。因此,通过中医药调节自噬过程,扶正祛邪,可能成为防治卵巢早衰的有效途径。基于这一理论,文章拟以正邪平衡为切入点,从宏观和微观角度探讨细胞自噬在卵巢早衰中的作用,旨在为中西医结合治疗卵巢早衰提供新的方向和方法。这将有助于中医理论的现代化,并提供新的理论支持。
Premature ovarian failure(POF)refers to a serious reproductive system disease with abnormal menstruation,disordered estrogen levels,and decreased fertility as the main clinical manifestations in women before the age of 40.Autophagy is a key mechanism of mammalian cell metabolism and plays a key role in the pathogenesis of premature ovarian failure.The“positive and negative”theory,as an important theory to describe the occurrence and development of diseases,is closely related to the development of premature ovarian failure.In this regard,the“positive and negative”theory emphasizes the dynamic balance between positive and negative qi,which is consistent with the function of cell autophagy in maintaining the health of the body.Therefore,regulating the autophagy process through traditional Chinese medicine and strengthening the positive and eliminating the negative qi may become an effective way to prevent and treat premature ovarian failure.Based on this theory,this paper intends to take the balance of positive and negative as the starting point to explore the role of cell autophagy in premature ovarian failure from a macroscopic and microscopic perspective,aiming to provide new directions and methods for the treatment of premature ovarian failure with the combination of traditional Chinese and Western medicine.This will contribute to the modernization of traditional Chinese medicine theory and provide new theoretical support.
作者
唐英
王小雪
吴娜娜
骆江利
蒲翔
TANG Ying;WANG Xiaoxue;WU Nana;LUO Jiangli;PU Xiang(Guizhou University of Traditional Chinese Medicine,Guizhou Guiyang 550025,China)
出处
《中医药临床杂志》
2025年第5期838-843,共6页
Clinical Journal of Traditional Chinese Medicine
基金
国家自然科学基金(82260897)。
关键词
卵巢早衰
自噬
正邪理论
中医药
Premature ovarian failure
Autophagy
Positive and negative theory
Traditional Chinese medicine
