摘要
目的采用两样本孟德尔随机化(MR)方法探讨静脉血栓栓塞症(VTE)与胎盘异常之间的因果关系。方法使用公开发表的全基因组关联研究汇总数据,以静脉血栓栓塞症相关的遗传位点作为工具变量,采用逆方差加权法(IVW)作为主要的分析方法,评估VTE与胎盘早剥、胎盘滞留(出血)、胎盘滞留(无出血)之间的因果关系。并采用Cochran’s Q检验,MR-PRESSO、MR-Egger回归法、留一法(leave-one-out)进行敏感性分析。结果IVW结果显示VTE与胎盘早剥呈负相关(OR=0.750,95%CI:0.598~0.940);VTE与胎盘滞留(出血)呈正相关(OR=1.150,95%CI:1.053~1.256);暂未发现VTE与胎盘滞留(无出血)之间存在相关性(OR=1.086,95%CI:0.998~1.183)。多种敏感性分析结果表明主分析具有稳健性。结论VTE与胎盘早剥、胎盘滞留(出血)有相关性,但与胎盘滞留(无出血)没有相关性。
Objective To explore the causal relationship between venous thromboembolism(VTE)and placental ab-normality using two-sample Mendelian randomization(MR).Methods Using the aggregated data of published genome-wide association studies,inverse variance weighted(IvW)was adopted as the main analysis method,with the genetic loci associ-ated with VTE as the instrumental variable.IVW was used as the primary analysis method to evaluate the causal relationship between VTE and placental abruption,retained placenta(haemorrhage),and retained placenta(without haemorrhage).Coch-ran's Q test,MR-PRESSO,MR-Egger regression and leave one out method were used for sensitivity analysis.Results IVW results showed that VTE was negatively correlated with placental abruption(OR=0.750,95%CI:0.598-0.940);VTE was posi-tively correlated with retained placenta(haemorrhage)(OR=1.150,95%CI:1.053-1.256);no association was found between VTE and retained placenta(without haemorrhage)(OR=1.086,95%CI:0.998-1.183).Conclusion VTE was associated with placental abruption and retained placenta(haemorrhage),but not with retained placenta(without haemorrhage).
作者
韩佳佳
李萍
李洪俞
魏欣
牟凯
HAN Jiajia;LI Ping;LI Hongyu;WEI Xin;MOU Kai(Department of Medical Genetics,Zibo Maternal and Child Health Hospital,Zibo,Shandong 255000,China)
出处
《中国优生与遗传杂志》
2025年第2期293-298,共6页
Chinese Journal of Birth Health & Heredity
基金
淄博市妇幼保健领域科研创新与科技引领计划项目(ZBFY2023013)。
关键词
孟德尔随机化
静脉血栓栓塞症
胎盘早剥
胎盘滞留
Mendelian randomization
venous thromboembolism
placental abruption
retained placenta
