摘要
Background and Objectives:Malnutrition is associated with pulmonary tuberculosis(PTB).The aim of this study is to investigate the association between persistent malnutrition and the effect of PTB treatment.Methods and Study Design:A total of 915 PTB patients were included.Baseline demographic information,anthropometry,and nutritional indicators were measured.The treatment effect was assessed by combinations of clinical manifestations,sputum smear,chest computerized tomography,gastrointestinal symptoms,and the indexes of liver function.Persistent malnutrition was considered when one or more indicators of malnutrition were lower than the reference standards in two tests on admission and after one month of treatment.Clinical symptom score(TB score)was used to assess the clinical manifestations.The generalized estimating equation(GEE)was used to assess the associations.Results:In GEE analyses,patients with underweight had a higher incidence of TB score>3(OR=2.95;95%CI,2.28-3.82)and lung cavitation(OR=1.36;95%CI,1.05-1.76).Hypoproteinemia was associated with a higher risk of TB score>3(OR=2.73;95%CI,2.08-3.59)and sputum positive(OR=2.69;95%CI,2.08-3.49).Anemia was associated with a higher risk of TB score>3(OR=1.73;95%CI,1.33-2.26),lung cavitation(OR=1.39;95%CI,1.19-1.63),and sputum positive(OR=2.23;95%CI,1.72-2.88).Lymphocytopenia was associated with a higher risk of gastrointestinal adverse reactions(OR=1.47;95%CI,1.17-1.83).Conclusions:Persistent malnutrition within one month of treatment can adversely affect anti-tuberculosis treatment.Nutritional status during anti-tuberculosis treatment should be continuously monitored.
基金
supported by the National Natural Science Foundation of China(81872610)
Danone nutrition research and education fund Project(DIC2018-09).
